Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Novel processing technique to produce three dimensional polyvinyl alcohol/maghemite nanofiber scaffold suitable for hard tissues

    Access Status
    Fulltext not available
    Authors
    Ngadiman, N.
    Yusof, N.
    Idris, A.
    Fallahiarezoudar, E.
    Kurniawan, Denni
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Ngadiman, N. and Yusof, N. and Idris, A. and Fallahiarezoudar, E. and Kurniawan, D. 2018. Novel processing technique to produce three dimensional polyvinyl alcohol/maghemite nanofiber scaffold suitable for hard tissues. Polymers. 10 (4): Article ID 353.
    Source Title
    Polymers
    DOI
    10.3390/polym10040353
    ISSN
    2073-4360
    School
    Curtin Malaysia
    URI
    http://hdl.handle.net/20.500.11937/68040
    Collection
    • Curtin Research Publications
    Abstract

    Fabrication of three dimensional (3D) tissue engineering scaffolds, particularly for hard tissues remains a challenge. Electrospinning has been used to fabricate scaffolds made from polymeric materials which are suitable for hard tissues. The electrospun scaffolds also have structural arrangement that mimics the natural extracellular matrix. However, electrospinning has a limitation in terms of scaffold layer thickness that it can fabricate. Combining electrospinning with other processes is the way forward, and in this proposed technique, the basic shape of the scaffold is obtained by a fused deposition modelling (FDM) three dimensional (3D) printing machine using the partially hydrolysed polyvinyl alcohol (PVA) as the filament material. The 3D printed PVA becomes a template to be placed inside a mould which is then filled with the fully hydrolysed PVA/maghemite (γ-Fe 2 O 3 ) solution. After the content in the mould solidified, the mould is opened and the content is freeze dried and immersed in water to dissolve the template. The 3D structure made of PVA/maghemite is then layered by electrospun PVA/maghemite fibers, resulting in 3D tissue engineering scaffold made from PVA/maghemite. The morphology and mechanical properties (strength and stiffness) were analysed and in vitro tests by degradation test and cell penetration were also performed. It was revealed that internally, the 3D scaffold has milli- and microporous structures whilst externally; it has a nanoporous structure as a result of the electrospun layer. The 3D scaffold has a compressive strength of 78.7 ± 0.6 MPa and a Young's modulus of 1.43 ± 0.82 GPa, which are within the expected range for hard tissue engineering scaffolds. Initial biocompatibility tests on cell penetration revealed that the scaffold can support growth of human fibroblast cells. Overall, the proposed processing technique which combines 3D printing process, thermal inversion phase separation (TIPS) method and electrospinning process has the potential for producing hard tissue engineering 3D scaffolds.

    Related items

    Showing items related by title, author, creator and subject.

    • Fabricating high mechanical strength gamma Fe2O3 nanoparticles filled poly(vinyl alcohol) nanofiber using electrospinning process potentially for tissue engineering scaffold
      Ngadiman, N.; Mohd Yusof, N.; Idris, A.; Kurniawan, Denni; Fallahiarezoudar, E. (2017)
      The use of electrospinning has gained substantial interest in the development of tissue engineering scaffolds due to its ability to produce nanoscale fibers which can mimic the geometry of extracellular tissues. Besides ...
    • Developments in tissue engineering scaffolding using an electrospinning process
      Ngadiman, N.; Noordin, M.; Idris, A.; Kurniawan, Denni; Fallahiarezoudar, E.; Sudin, I. (2017)
      © 2017 Nova Science Publishers, Inc. Electrospinning is a simple and efficient process in producing nanofibers. The use of an electrospinning process in fabricating tissue engineering scaffolds has received great attention ...
    • A review of evolution of electrospun tissue engineering scaffold: From two dimensions to three dimensions
      Ngadiman, N.; Noordin, M.; Idris, A.; Kurniawan, Denni (2017)
      The potential of electrospinning process to fabricate ultrafine fibers as building blocks for tissue engineering scaffolds is well recognized. The scaffold construct produced by electrospinning process depends on the ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.