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    A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines

    Access Status
    Fulltext not available
    Authors
    Lim, F.
    Halcovitch, N.
    Tiekink, E.
    Dolzhenko, Anton
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Lim, F. and Halcovitch, N. and Tiekink, E. and Dolzhenko, A. 2018. A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines. Tetrahedron. 74 (15): pp. 1868-1879.
    Source Title
    Tetrahedron
    DOI
    10.1016/j.tet.2018.02.054
    ISSN
    0040-4020
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/68154
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Elsevier Ltd A series of 5-aza-9-deaza- analogues of purine was effectively prepared using highly selective annulation of 1,3,5-triazine ring onto 5-aminopyrazole-4-carboxylates via a one-pot, multicomponent, microwave-assisted approach. The products were obtained in good yields and high purity. This catalyst-free method was demonstrated to be scalable and highly reproducible in different microwave reactors. Some structural features of the prepared compounds were studied in details using dynamic NMR spectroscopy and X-ray crystallography.

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