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    Aptameric Formulation for Enhanced Biopharmaceutical Delivery

    Tan KX 2018.pdf (8.094Mb)
    Access Status
    Open access
    Authors
    Tan, Kei Xian
    Date
    2018
    Supervisor
    Prof Michael Danquah
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    Faculty
    Engineering and Science (Sarawak)
    School
    Curtin Malaysia
    URI
    http://hdl.handle.net/20.500.11937/68408
    Collection
    • Curtin Theses
    Abstract

    This research work developed a novel polymeric carrier system for targeted drug delivery to specific body sites. It utilized unique molecular probes called aptamers that navigate the complexity of mammalian cell systems and present drug molecules to desired locations. The aptamer molecules were tagged onto polymer drug carriers as binding ligands to direct an efficient path towards targeted delivery, avoiding unwanted effects on nontargeted cells and potentially addressing side effects of chemotherapy.

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