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dc.contributor.authorPu, Y.
dc.contributor.authorLu, J.
dc.contributor.authorWang, D.
dc.contributor.authorCai, F.
dc.contributor.authorWang, J.
dc.contributor.authorFoster, Neil
dc.contributor.authorChen, Jianping
dc.identifier.citationPu, Y. and Lu, J. and Wang, D. and Cai, F. and Wang, J. and Foster, N. and Chen, J. 2017. Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters. Powder Technology. 321: pp. 197-203.

© 2017 Elsevier B.V. Ciprofloxacin (CIP) has been widely used to treat many types of bacterial infections. Herein, we reported a green approach for preparation of CIP nanoparticles via solvent anti-solvent precipitation by using subcritical water-ethanol mixture as the solvent. The solubility of CIP in subcritical water-ethanol mixture (with various ethanol ratio of 0, 5, and 20 wt%) at the temperature range from 100 °C to 170 °C and constant pressure of 4 MPa were measured. The chemical structure of CIP was stable after processed in subcritical water-ethanol mixture at up to 170 °C, confirmed by Fourier transformed infrared analysis. The obtained solubility data of CIP were correlated using a modified Apelblat model and the results of the predicted solubility show good agreement with the experimental value. The nanonization of CIP via solvent anti-solvent precipitation process that used the tunable solvent power of subcritical water-ethanol mixture was conducted. Two kinds of no-ionic, hydrophilic polymer, including polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG), were introduced as stabilizers in the precipitation process to obtain CIP nanoparticle with improved dissolution rate. These results show that as-synthesized CIP nanoparticles are promising for oral administration of CIP drugs.

dc.titleNanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters
dc.typeJournal Article
dcterms.source.titlePowder Technology
curtin.departmentWASM: Minerals, Energy and Chemical Engineering (WASM-MECE)
curtin.accessStatusFulltext not available

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