Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

Duczynski, J.; Fuller, Rebecca; Stewart, S.

doi:10.1071/CH16097

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Authors

Duczynski, J.

Fuller, Rebecca

Stewart, S.

Date

2016

Type

Journal Article

Metadata

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Citation

Duczynski, J. and Fuller, R. and Stewart, S. 2016. Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions. Australian Journal of Chemistry. 69 (10): pp. 1172-1179.

Source Title

Australian Journal of Chemistry

DOI

10.1071/CH16097

ISSN

0004-9425

School

School of Molecular and Life Sciences (MLS)

URI

http://hdl.handle.net/20.500.11937/68534

Collection

Curtin Research Publications

Abstract

© The Authors 2016. Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.