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    Reduction-Responsive Codelivery System Based on a Metal-Organic Framework for Eliciting Potent Cellular Immune Response

    Access Status
    Fulltext not available
    Authors
    Yang, Y.
    Chen, Q.
    Wu, Jian-Ping
    Kirk, Brett
    Xu, J.
    Liu, Z.
    Xue, W.
    Date
    2018
    Type
    Journal Article
    
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    Citation
    Yang, Y. and Chen, Q. and Wu, J. and Kirk, B. and Xu, J. and Liu, Z. and Xue, W. 2018. Reduction-Responsive Codelivery System Based on a Metal-Organic Framework for Eliciting Potent Cellular Immune Response. ACS Applied Materials and Interfaces. 10 (15): pp. 12463-12473.
    Source Title
    ACS Applied Materials and Interfaces
    DOI
    10.1021/acsami.8b01680
    ISSN
    1944-8244
    School
    School of Civil and Mechanical Engineering (CME)
    URI
    http://hdl.handle.net/20.500.11937/68561
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 American Chemical Society. Utilizing nanoparticles to deliver subunit vaccines can be viewed as a promising strategy for enhancing the immune response, especially with regard to cellular immunity to fight against infectious viruses and malignant cancer. Nevertheless, its applications are still far from practicality because of some limitations such as high cost, non-biocompatibility, non-biodegradability, and the inefficient stimulation of cytotoxic T lymphocyte (CTL) response. In this study, we use metal-organic framework (MOF) MIL-101-Fe-NH 2 nanoparticles as carriers to fabricate an innovative reduction-responsive antigen delivery system for cotransporting the antigen model ovalbumin (OVA) and an immune adjuvant, unmethylated cytosine-phosphate-guanine (CpG) oligonucleotide. In vitro cellular tests show that the MOF nanoparticles can not only greatly improve the uptake of OVA by the antigen-presenting cells but also smartly deliver both OVA and CpG into the same cell. By feat of the reductively controllable release of OVA and the promoting function of CpG, the delivery system can elicit strong cellular immunity and CTL response in mice. Moreover, the increased frequencies of effector memory T cells inspired by the delivery system indicate that it can induce a potent immune memory response. These results demonstrate that MOF nanoparticles are excellent vehicles for codelivering antigen and immune adjuvant and may find wider applications in biomedical fields.

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