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    Determination of the mutagenic potential of commonly marketed Ghanaian medicinal plant formulations using the bacterial reverse mutation assay

    228248_Senayah 2015.pdf (3.045Mb)
    Access Status
    Open access
    Authors
    Senayah, Fidelia
    Date
    2015
    Supervisor
    Dr. Paul Costantino
    Assoc. Prof. T.K.S. Mukkur
    Type
    Thesis
    Award
    MPhil
    
    Metadata
    Show full item record
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/687
    Collection
    • Curtin Theses
    Abstract

    The mutagenic potential of nine commonly marketed Ghanaian medicinal plant aqueous extract formulations determined using the bacterial reverse mutation assay (Ames test) were found to be non-mutagenic. In contrast, one extract, E8 was found to be anti-mutagenic as determined using either a frameshift or a base pair substitution mutant of S. typhimurium in the metabolic activation system. E8 was also found to possess antimicrobial activity against Moraxella catarrhalis.

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