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    Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution during Pregnancy

    266570.pdf (838.7Kb)
    Access Status
    Open access
    Authors
    Warren, J.
    Son, J.
    Pereira, Gavin
    Leaderer, B.
    Bell, M.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Warren, J. and Son, J. and Pereira, G. and Leaderer, B. and Bell, M. 2018. Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution during Pregnancy. American Journal of Epidemiology. 187 (5): pp. 992-1000.
    Source Title
    American Journal of Epidemiology
    DOI
    10.1093/aje/kwx335
    ISSN
    0002-9262
    School
    School of Public Health
    Remarks

    This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Epidemiology following peer review. The version of record as cited above is available online at: http://doi.org/10.1093/aje/kwx335

    URI
    http://hdl.handle.net/20.500.11937/68708
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 The Author(s). Identifying periods of increased vulnerability to air pollution during pregnancy with respect to the development of adverse birth outcomes can improve understanding of possible mechanisms of disease development and provide guidelines for protection of the child. Exposure to air pollution during pregnancy is typically based on the mother's residence at delivery, potentially resulting in exposure misclassification and biasing the estimation of critical windows of pregnancy. In this study, we determined the impact of maternal residential mobility during pregnancy on defining weekly exposure to particulate matter less than or equal to 10 µm in aerodynamic diameter (PM 10) and estimating windows of susceptibility to term low birth weight. We utilized data sets from 4 Connecticut birth cohorts (1988-2008) that included information on all residential addresses between conception and delivery for each woman. We designed a simulation study to investigate the impact of increasing levels of mobility on identification of critical windows. Increased PM 10 exposure during pregnancy weeks 16-18 was associated with an increased probability of term low birth weight. Ignoring residential mobility when defining weekly exposure had only a minor impact on the identification of critical windows for PM 10 and term low birth weight in the data application and simulation study. Identification of critical pregnancy windows was robust to exposure misclassification caused by ignoring residential mobility in these Connecticut birth cohorts.

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