Possible use of Punica granatum (Pomegranate) in cancer therapy
Embargo Lift Date
MetadataShow full item record
The intake of fruits has proven to reduce the risk and incidence of cancer worldwide and plays a crucial role in cancer prevention. Pomegranate (Punica granatum), which belongs to the Punicaceae family, is one such plant that contains beneficial nutrients as well as many bioactive components and important phytochemicals that can be attributed to cancer-related therapeutic purposes. Pomegranate possesses antioxidant, anti-inflammatory, anti-proliferative, anti-angiogenic, anti-invasive, and anti-metastatic properties, and induces apoptosis. It also down-regulates various signaling pathways such as NF-?B, PI3K/AKT/mTOR, and Wnt, and down-regulates the expression of genes that are responsible in cancer development, such as anti-apoptotic genes, MMPs, VEGF, c-met, cyclins, Cdks, and pro-inflammatory cytokines. Therefore, inclusion of the fruit in one's diet would assist in a healthy life protected from cancer and also act as an effective chemotherapeutic with no toxic side effects.
Showing items related by title, author, creator and subject.
Sethi, G.; Shanmugam, M.; Warrier, S.; Merarchi, M.; Arfuso, Frank; Kumar, A.; Bishayee, A. (2018)© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Novel and alternative options are being adopted to combat the initiation and progression of human cancers. One of the approaches is the use of molecules isolated ...
Tomek, M.; Akiyama, T.; Dass, Crispin (2012)Objectives: Bcl-2 is a protein that inhibits apoptosis, leading to cell survival. The Bcl-2 family has six different anti-apoptotic proteins, three pro-apoptotic proteins that are similar in structure, and other integrating ...
Ko, J.; Sethi, G.; Um, J.; Shanmugam, M.; Arfuso, Frank; Kumar, Alan Prem; Bishayee, A.; Ahn, K. (2017)© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, ...