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dc.contributor.authorDe Angelis Rigotti, F.
dc.contributor.authorDe Gassart, A.
dc.contributor.authorPforr, Christof
dc.contributor.authorCano, F.
dc.contributor.authorN'Guessan, P.
dc.contributor.authorCombes, A.
dc.contributor.authorCamossetto, V.
dc.contributor.authorLehner, P.
dc.contributor.authorPierre, P.
dc.contributor.authorGatti, E.
dc.date.accessioned2018-06-29T12:28:38Z
dc.date.available2018-06-29T12:28:38Z
dc.date.created2018-06-29T12:08:38Z
dc.date.issued2017
dc.identifier.citationDe Angelis Rigotti, F. and De Gassart, A. and Pforr, C. and Cano, F. and N'Guessan, P. and Combes, A. and Camossetto, V. et al. 2017. MARCH9-mediated ubiquitination regulates MHC i export from the TGN. Immunology and Cell Biology. 95 (9): pp. 753-764.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/69150
dc.identifier.doi10.1038/icb.2017.44
dc.description.abstract

© 2017 Australasian Society for Immunology Inc. All rights reserved. Given the heterogeneous nature of antigens, major histocompatibility complex class I (MHC I) intracellular transport intersects with multiple degradation pathways for efficient peptide loading and presentation to cytotoxic T cells. MHC I loading with peptides in the endoplasmic reticulum (ER) is a tightly regulated process, while post-ER intracellular transport is considered to occur by default, leading to peptide-bearing MHC I delivery to the plasma membrane. We show here that MHC I traffic is submitted to a previously uncharacterized sorting step at the trans Golgi network (TGN), dependent on the ubiquitination of its cytoplasmic tail lysine residues. MHC I ubiquitination is mediated by the E3 ligase membrane-associated RING-CH 9 (MARCH9) and allows MHC I access to Syntaxin 6-positive endosomal compartments. We further show that MARCH9 can also target the human MHC I-like lipid antigen-presentation molecule CD1a. MARCH9 expression is modulated by microbial pattern exposure in dendritic cells (DCs), thus revealing the role of this ubiquitin E3 ligase in coordinating MHC I access to endosomes and DC activation for efficient antigen cross-presentation.

dc.publisherNature Publishing Group
dc.titleMARCH9-mediated ubiquitination regulates MHC i export from the TGN
dc.typeJournal Article
dcterms.source.volume95
dcterms.source.number9
dcterms.source.startPage753
dcterms.source.endPage764
dcterms.source.issn0818-9641
dcterms.source.titleImmunology and Cell Biology
curtin.departmentSchool of Marketing
curtin.accessStatusFulltext not available


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