MARCH9-mediated ubiquitination regulates MHC i export from the TGN
dc.contributor.author | De Angelis Rigotti, F. | |
dc.contributor.author | De Gassart, A. | |
dc.contributor.author | Pforr, Christof | |
dc.contributor.author | Cano, F. | |
dc.contributor.author | N'Guessan, P. | |
dc.contributor.author | Combes, A. | |
dc.contributor.author | Camossetto, V. | |
dc.contributor.author | Lehner, P. | |
dc.contributor.author | Pierre, P. | |
dc.contributor.author | Gatti, E. | |
dc.date.accessioned | 2018-06-29T12:28:38Z | |
dc.date.available | 2018-06-29T12:28:38Z | |
dc.date.created | 2018-06-29T12:08:38Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | De Angelis Rigotti, F. and De Gassart, A. and Pforr, C. and Cano, F. and N'Guessan, P. and Combes, A. and Camossetto, V. et al. 2017. MARCH9-mediated ubiquitination regulates MHC i export from the TGN. Immunology and Cell Biology. 95 (9): pp. 753-764. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/69150 | |
dc.identifier.doi | 10.1038/icb.2017.44 | |
dc.description.abstract |
© 2017 Australasian Society for Immunology Inc. All rights reserved. Given the heterogeneous nature of antigens, major histocompatibility complex class I (MHC I) intracellular transport intersects with multiple degradation pathways for efficient peptide loading and presentation to cytotoxic T cells. MHC I loading with peptides in the endoplasmic reticulum (ER) is a tightly regulated process, while post-ER intracellular transport is considered to occur by default, leading to peptide-bearing MHC I delivery to the plasma membrane. We show here that MHC I traffic is submitted to a previously uncharacterized sorting step at the trans Golgi network (TGN), dependent on the ubiquitination of its cytoplasmic tail lysine residues. MHC I ubiquitination is mediated by the E3 ligase membrane-associated RING-CH 9 (MARCH9) and allows MHC I access to Syntaxin 6-positive endosomal compartments. We further show that MARCH9 can also target the human MHC I-like lipid antigen-presentation molecule CD1a. MARCH9 expression is modulated by microbial pattern exposure in dendritic cells (DCs), thus revealing the role of this ubiquitin E3 ligase in coordinating MHC I access to endosomes and DC activation for efficient antigen cross-presentation. | |
dc.publisher | Nature Publishing Group | |
dc.title | MARCH9-mediated ubiquitination regulates MHC i export from the TGN | |
dc.type | Journal Article | |
dcterms.source.volume | 95 | |
dcterms.source.number | 9 | |
dcterms.source.startPage | 753 | |
dcterms.source.endPage | 764 | |
dcterms.source.issn | 0818-9641 | |
dcterms.source.title | Immunology and Cell Biology | |
curtin.department | School of Marketing | |
curtin.accessStatus | Fulltext not available |
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