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dc.contributor.authorWang, Y.
dc.contributor.authorJi, X.
dc.contributor.authorPang, P.
dc.contributor.authorShi, Y.
dc.contributor.authorDai, J.
dc.contributor.authorXu, J.
dc.contributor.authorWu, Jian-Ping
dc.contributor.authorKirk, Brett
dc.contributor.authorXue, W.
dc.date.accessioned2018-06-29T12:28:59Z
dc.date.available2018-06-29T12:28:59Z
dc.date.created2018-06-29T12:08:48Z
dc.date.issued2018
dc.identifier.citationWang, Y. and Ji, X. and Pang, P. and Shi, Y. and Dai, J. and Xu, J. and Wu, J. et al. 2018. Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy. Journal of Materials Chemistry B. 6 (16): pp. 2481-2488.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/69232
dc.identifier.doi10.1039/c8tb00233a
dc.description.abstract

© 2018 The Royal Society of Chemistry. Chemo-photothermal therapy has attracted tremendous attention due to its synergistic effect in killing cancer cells, making it one of the most efficient therapies. Although most of the applied core-shell hybrid nanoparticles (NPs) can perform such a function, the lowering of their thermal efficiency through polymer coating and limited drug loading capacity severely limit their performance. Janus NPs with exposed metal and a polymer/silica matrix show improved chemo- and photothermal-efficiency, but have a complicated synthesis, and their loading capacity for hydrophobic drugs still needs to be optimized. Herein, we report the facile synthesis of Janus NPs comprising Au nanorods (NRs) and a hydrophobic polydivinylbenzene (PDVB) matrix. The UV-vis extinction of the Janus NPs is in the near infrared region (the region used in medicine), which makes it an ideal candidate for photothermal therapy, and the hydrophobic PDVB component is a good anticancer drug (curcumin) carrier for chemotherapy. With this combination of chemo- and photothermal-effects, a significant decrease in cell viability, migration, and invasion was realised, making the material a promising biomedical candidate for the treatment of cancer.

dc.publisherR S C Publications
dc.titleSynthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy
dc.typeJournal Article
dcterms.source.volume6
dcterms.source.number16
dcterms.source.startPage2481
dcterms.source.endPage2488
dcterms.source.issn2050-7518
dcterms.source.titleJournal of Materials Chemistry B
curtin.departmentSchool of Civil and Mechanical Engineering (CME)
curtin.accessStatusFulltext not available


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