Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Bio-Spectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Ageing Mouse Model

    69402.pdf (1.064Mb)
    Access Status
    Open access
    Authors
    Fimognari, Nicholas
    Hollings, Ashley
    Lam, Virginie
    Tidy, Rebecca
    Kewish, C.
    Albrecht, Matthew
    Takechi, Ryu
    Mamo, John
    Hackett, Mark
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Fimognari, N. and Hollings, A. and Lam, V. and Tidy, R. and Kewish, C. and Albrecht, M. and Takechi, R. et al. 2018. Bio-Spectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Ageing Mouse Model. ACS Chemical Neuroscience. 9 (11): pp. 2774-2785.
    Source Title
    ACS Chemical Neuroscience
    DOI
    10.1021/acschemneuro.8b00193
    ISSN
    1948-7193
    School
    School of Public Health
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/1064567
    URI
    http://hdl.handle.net/20.500.11937/69235
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 American Chemical Society. Western society is facing a health epidemic due to the increasing incidence of dementia in ageing populations, and there are still few effective diagnostic methods, minimal treatment options, and no cure. Ageing is the greatest risk factor for memory loss that occurs during the natural ageing process, as well as being the greatest risk factor for neurodegenerative disease such as Alzheimer's disease. Therefore, greater understanding of the biochemical pathways that drive a healthy ageing brain towards dementia (pathological ageing or Alzheimer's disease), is required to accelerate the development of improved diagnostics and therapies. Unfortunately, many animal models of dementia model chronic amyloid precursor protein over-expression, which although highly relevant to mechanisms of amyloidosis and familial Alzheimer's disease, does not model well dementia during the natural ageing process. A promising animal model reported to model mechanisms of accelerated natural ageing and memory impairments, is the senescence accelerated murine prone strain 8 (SAMP8), which has been adopted by many research group to study the biochemical transitions that occur during brain ageing. A limitation to traditional methods of biochemical characterisation is that many important biochemical and elemental markers (lipid saturation, lactate, transition metals) cannot be imaged at meso- or micro-spatial resolution. Therefore, in this investigation we report the first multi-modal biospectroscopic characterisation of the SAMP8 model, and have identified important biochemical and elemental alterations, and co-localisations, between 4 month old SAMP8 mice and the relevant control (SAMR1) mice. Specifically, we demonstrate direct evidence of altered metabolism and disturbed lipid homeostasis within corpus callosum white matter, in addition to localised hippocampal metal deficiencies, in the accelerated ageing phenotype. Such findings have important implication for future research aimed at elucidating specific biochemical pathways for therapeutic intervention.

    Related items

    Showing items related by title, author, creator and subject.

    • A multistate model of health transitions in older people: a secondary analysis of ASPREE clinical trial data
      Neumann, J.T.; Thao, L.T.P.; Callander, E.; Carr, P.R.; Qaderi, V.; Nelson, M.R.; Reid, Christopher ; Woods, R.L.; Orchard, S.G.; Wolfe, R.; Polekhina, G.; Williamson, J.D.; Trauer, J.M.; Newman, A.B.; Murray, A.M.; Ernst, M.E.; Tonkin, A.M.; McNeil, J.J. (2022)
      Background: Understanding the nature of transitions from a healthy state to chronic diseases and death is important for planning health-care system requirements and interventions. We aimed to quantify the trajectories of ...
    • Body adiposity in later life and the incidence of dementia: The health in men study
      Power, B.; Alfonso, Helman; Flicker, L.; Hankey, G.; Yeap, B.; Almeida, O. (2011)
      Objective: To determine if adiposity in later life increases dementia hazard. Methods: Cohort study of 12,047 men aged 65-84 years living in Perth, Australia. Adiposity exposures were baseline body mass index (BMI), waist ...
    • Diet, nutrients and metabolism: Cogs in the wheel driving Alzheimer's disease pathology?
      Creegan, Rhona; Hunt, Wendy; McManus, Alexandra; Rainey-Smith, S. (2015)
      Alzheimer's disease (AD), the most common form of dementia, is a chronic, progressive neurodegenerative disease that manifests clinically as a slow global decline in cognitive function, including deterioration of memory, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.