A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines
dc.contributor.author | Lim, F. | |
dc.contributor.author | Tan, L. | |
dc.contributor.author | Tiekink, E. | |
dc.contributor.author | Dolzhenko, Anton | |
dc.date.accessioned | 2018-06-29T12:29:00Z | |
dc.date.available | 2018-06-29T12:29:00Z | |
dc.date.created | 2018-06-29T12:08:42Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Lim, F. and Tan, L. and Tiekink, E. and Dolzhenko, A. 2018. A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines. RSC Advances. 8 (38): pp. 21495-21504. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/69236 | |
dc.identifier.doi | 10.1039/c8ra03703e | |
dc.description.abstract |
© The Royal Society of Chemistry 2018. A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1,2-a][1,3,5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography. | |
dc.publisher | Royal Society of Chemistry | |
dc.title | A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines | |
dc.type | Journal Article | |
dcterms.source.volume | 8 | |
dcterms.source.number | 38 | |
dcterms.source.startPage | 21495 | |
dcterms.source.endPage | 21504 | |
dcterms.source.issn | 2046-2069 | |
dcterms.source.title | RSC Advances | |
curtin.department | School of Pharmacy and Biomedical Sciences | |
curtin.accessStatus | Fulltext not available |
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