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    Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling

    Pohl S 2018.pdf (32.58Mb)
    Access Status
    Open access
    Authors
    Pohl, Sebastian Öther-Gee
    Date
    2018
    Supervisor
    Prof. Arunasalam Dharmarajan
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/69390
    Collection
    • Curtin Theses
    Abstract

    Breast cancer is the most common cause of malignancy affecting women worldwide. This thesis focusses on the role of DDX20 in regulating Wnt/β-catenin signalling and its impact on cell fate in triple-negative breast cancer (TNBC). The results of this study demonstrated a new role for DDX20-mediated Wnt signalling governing intracellular redox and mitochondrial function. Furthermore, we have determined that DDX20 is an essential regulator of Wnt/β-catenin signalling in TNBC stem cells.

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