Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling
Access Status
Open access
Authors
Date
2018Supervisor
Prof. Arunasalam Dharmarajan
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
School of Pharmacy and Biomedical Sciences
Collection
Abstract
Breast cancer is the most common cause of malignancy affecting women worldwide. This thesis focusses on the role of DDX20 in regulating Wnt/β-catenin signalling and its impact on cell fate in triple-negative breast cancer (TNBC). The results of this study demonstrated a new role for DDX20-mediated Wnt signalling governing intracellular redox and mitochondrial function. Furthermore, we have determined that DDX20 is an essential regulator of Wnt/β-catenin signalling in TNBC stem cells.
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