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dc.contributor.authorPohl, Sebastian Öther-Gee
dc.contributor.supervisorProf. Arunasalam Dharmarajanen_US

Breast cancer is the most common cause of malignancy affecting women worldwide. This thesis focusses on the role of DDX20 in regulating Wnt/β-catenin signalling and its impact on cell fate in triple-negative breast cancer (TNBC). The results of this study demonstrated a new role for DDX20-mediated Wnt signalling governing intracellular redox and mitochondrial function. Furthermore, we have determined that DDX20 is an essential regulator of Wnt/β-catenin signalling in TNBC stem cells.

dc.publisherCurtin Universityen_US
dc.titleMediation of triple-negative breast cancer cell fate via cellular redox and Wnt signallingen_US
curtin.departmentSchool of Pharmacy and Biomedical Sciencesen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US

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