Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling
| dc.contributor.author | Pohl, Sebastian Öther-Gee | |
| dc.contributor.supervisor | Prof. Arunasalam Dharmarajan | en_US |
| dc.date.accessioned | 2018-08-03T02:04:20Z | |
| dc.date.available | 2018-08-03T02:04:20Z | |
| dc.date.issued | 2018 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/69390 | |
| dc.description.abstract |
Breast cancer is the most common cause of malignancy affecting women worldwide. This thesis focusses on the role of DDX20 in regulating Wnt/β-catenin signalling and its impact on cell fate in triple-negative breast cancer (TNBC). The results of this study demonstrated a new role for DDX20-mediated Wnt signalling governing intracellular redox and mitochondrial function. Furthermore, we have determined that DDX20 is an essential regulator of Wnt/β-catenin signalling in TNBC stem cells. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | School of Pharmacy and Biomedical Sciences | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |