Long-term clinical outcomes of transient and persistent no-reflow following percutaneous coronary intervention (PCI): A multicentre Australian registry
MetadataShow full item record
© 2018 Europa Digital & Publishing. All rights reserved. Aims: The aim of the study was to evaluate long-term outcomes of transient versus persistent no-reflow. Methods and results: A total of 17,547 patients with normal flow post percutaneous coronary intervention (PCI) were compared to 590 patients (3.2%) with transient no-reflow and 144 patients (0.8%) with persistent no-reflow. Long-term all-cause mortality was obtained by linkage with the National Death Index (NDI). No-reflow patients were more likely to have presented with ST-elevation myocardial infarction (STEMI), out-of-hospital cardiac arrest (OHCA) or cardiogenic shock (all p<0.01). Long-term NDI-linked all-cause mortality was highest in patients with persistent no-reflow (31%) followed by transient no-reflow (22%) and normal flow (14%) over a median follow-up of 5.2, 5.5 and 4.5 years, respectively (all p<0.0001). Kaplan-Meier survival estimates demonstrated a graded increase in all-cause mortality from normal flow, to transient to persistent no-reflow (p<0.01), with the highest mortality occurring early (<30 days) in the persistent no-reflow group (p<0.0001). Multivariate Cox proportional hazards modelling identified glomerular filtration rate <30 mL/min, ejection fraction <30%, persistent no-reflow and transient no-reflow as independent predictors of increased hazard for all-cause mortality (all p<0.05). Conclusions: Transient and persistent no-reflow were associated with a stepwise reduction in long-term survival. The presence of even transient no-reflow appears to be an important predictor of adverse long-term outcome.
Showing items related by title, author, creator and subject.
Short- and long-term association of lipid-lowering drug treatment and cardiovascular disease by estimated absolute risk in the Second Australian National Blood Pressure studyHo, C.; Chowdhury, E.; Breslin, M.; Doust, J.; Reid, C.; Wing, L.; Nelson, M.; Beilin, L.; Jennings, G.; Johnston, C.; Macdonald, G.; Marley, J.; McNeil, J.; Morgan, T.; Reid, Christopher; Ryan, P.; West, M.; Wing, L. (2018)© 2018 National Lipid Association Background: There is currently insufficient evidence to support the use of lipid-lowering drug treatment (LLT) for primary prevention of cardiovascular disease (CVD) in the elderly. ...
Short-and long-term survival in treated elderly hypertensive patients with or without diabetes: Findings from the second Australian national blood pressure studyChowdhury, E.; Owen, A.; Ademi, Z.; Krum, H.; Johnston, C.; Wing, L.; Nelson, M.; Reid, Christopher (2014)Background: We sought to determine the incidence of newly diagnosed diabetes in treated elderly hypertensive patients and the prognostic impact of diabetes on long-term survival. Methods: The Second Australian National ...
Does the subtype of acute coronary syndrome treated by percutaneous coronary intervention predict long-term clinical outcomes?Biswas, S.; Andrianopoulos, N.; Papapostolou, S.; Noaman, S.; Duffy, S.; Lefkovits, J.; Brennan, Angela; Walton, A.; Shaw, J.; Ajani, A.; Clark, D.; Freeman, M.; Hiew, C.; Oqueli, E.; Reid, C.; Stub, D.; Chan, W. (2018)© The Author 2017. Aims The prognosis of patients undergoing percutaneous coronary intervention (PCI) for different subtypes of acute coronary syndromes (ACS) remains unclear. We compared short- and long-term mortality ...