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dc.contributor.authorPadmavathi, G.
dc.contributor.authorBanik, K.
dc.contributor.authorMonisha, J.
dc.contributor.authorBordoloi, D.
dc.contributor.authorShabnam, B.
dc.contributor.authorArfuso, Frank
dc.contributor.authorSethi, G.
dc.contributor.authorFan, L.
dc.contributor.authorKunnumakkara, A.
dc.identifier.citationPadmavathi, G. and Banik, K. and Monisha, J. and Bordoloi, D. and Shabnam, B. and Arfuso, F. and Sethi, G. et al. 2018. Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression. Cancer Letters. 432: pp. 260-271.

The tumor necrosis factor (TNF)-a- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, inflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with the development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancreas, prostate, and thyroid gland. Also, deregulation of these proteins was found to promote the essential hallmarks of cancer such as survival, tumor growth, proliferation, inhibition of apoptosis, angiogenesis, invasion, migration, and metastasis. Further, differential expression of these proteins in normal and cancer tissues and their association with tumor progression and prognosis signifies the potential diagnostic and prognostic values of TIPE proteins and their importance in cancer therapy. The current review summarizes the literature available thus far on the expression, function, and role of TIPE proteins in the development and maintenance of various cancers.

dc.titleNovel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression
dc.typeJournal Article
dcterms.source.titleCancer Letters
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available

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