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dc.contributor.authorKhazandi, M.
dc.contributor.authorAl-Farha, A.
dc.contributor.authorCoombs, Geoffrey
dc.contributor.authorO'Dea, M.
dc.contributor.authorPang, S.
dc.contributor.authorTrott, D.
dc.contributor.authorAviles, R.
dc.contributor.authorHemmatzadeh, F.
dc.contributor.authorVenter, H.
dc.contributor.authorOgunniyi, A.
dc.contributor.authorHoare, A.
dc.contributor.authorAbraham, S.
dc.contributor.authorPetrovski, K.
dc.date.accessioned2018-08-08T04:42:36Z
dc.date.available2018-08-08T04:42:36Z
dc.date.created2018-08-08T03:50:51Z
dc.date.issued2018
dc.identifier.citationKhazandi, M. and Al-Farha, A. and Coombs, G. and O'Dea, M. and Pang, S. and Trott, D. and Aviles, R. et al. 2018. Genomic characterization of coagulase-negative staphylococci including methicillin-resistant Staphylococcus sciuri causing bovine mastitis. Veterinary Microbiology. 219: pp. 17-22.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/69843
dc.identifier.doi10.1016/j.vetmic.2018.04.004
dc.description.abstract

Methicillin-resistant coagulase-negative staphylococci (MRCoNS) have recently emerged as a significant cause of bovine mastitis worldwide. Here we describe the isolation of MRCoNS from cases of bovine mastitis from a single dairy farm in Australia. Fourteen CoNS isolates were identified as MRCoNS on the basis of having an oxacillin MIC of =0.5 µg/mL. The isolates were speciated as S. chromogenes (n = 1) S. fleurettii (n = 1), S. haemolyticus (n = 2), S. sciuri (n = 5), S. simulans (n = 1) S. succinus (n = 2) and S. xylosus (n = 2). Five of the isolates (S. fleuretti, S. haemolyticus S. sciuri and two S. succinus) were mecA-positive. We also detected a previously described S. sciuri mecA homolog in four oxacillin-resistant S. sciuri isolates. The remainder of the putative MRCoNS did not contain any mecA-related resistance determinants in their genomes. Comparative genomic analysis of three previously published S. sciuri isolates, from humans, a squirrel and a cereal crop (rice), and a representative isolate from our study demonstrated clustering and a high degree of genetic homogeneity (>95%), suggesting S. sciuri has low host specificity. In conclusion, CoNS, in particular S. sciuri, may act as a reservoir for SCCmec elements that can easily be spread between different host species by direct cross-infection.

dc.publisherElsevier
dc.titleGenomic characterization of coagulase-negative staphylococci including methicillin-resistant Staphylococcus sciuri causing bovine mastitis
dc.typeJournal Article
dcterms.source.volume219
dcterms.source.startPage17
dcterms.source.endPage22
dcterms.source.issn0378-1135
dcterms.source.titleVeterinary Microbiology
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available


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