Genetic approaches in preeclampsia
Access Status
Authors
Date
2018Type
Metadata
Show full item recordCitation
Source Title
School
Collection
Abstract
Preeclampsia (PE) is a serious hypertensive disorder that affects up to 8% of all pregnancies annually. An established risk factor for PE is family history, clearly demonstrating an underlying genetic component to the disorder. To date, numerous genetic studies, using both the candidate gene and genome-wide approach, have been undertaken to tease out the genetic basis of PE and understand its origins. Such studies have identified some promising candidate genes such as STOX1 and ACVR2A. Nevertheless, researchers face ongoing challenges of replicating these genetic associations in different populations and performing the functional validation of identified genetic variants to determine their causality in the disorder. This chapter will review the genetic approaches used in the study of PE, discuss their limitations and possible confounders, and describe current strategies.
Related items
Showing items related by title, author, creator and subject.
-
Venville, Grady J. (1997)A journey into the past century of genetics history reveals transformations of the concept of the gene through notions of discrete units that obeyed Mendelian laws to the modem bewildering gene concept. We can no longer ...
-
Sheikhi, Abdullah (2008)Aim: This study aims to investigate the genetic components of Attention Deficit Hyperactivity Disorder (ADHD), Reading Disability (RD), and their comorbidity. Methods: Three approaches were applied to data from 2610 ...
-
He, Tianhua; Lamont, Byron; Krauss, S.; Enright, Neal (2010)Background and Aims: Landscape genetics combines approaches from population genetics and landscape ecology, increasing the scope for conceptual advances in biology. Banksia hookeriana comprises clusters of individuals ...