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dc.contributor.authorStrauß, L.
dc.contributor.authorStegger, M.
dc.contributor.authorAkpaka, P.
dc.contributor.authorAlabi, A.
dc.contributor.authorBreurec, S.
dc.contributor.authorCoombs, Geoffrey
dc.contributor.authorEgyir, B.
dc.contributor.authorLarsen, A.
dc.contributor.authorLaurent, F.
dc.contributor.authorMonecke, S.
dc.contributor.authorPeters, G.
dc.contributor.authorSkov, R.
dc.contributor.authorStrommenger, B.
dc.contributor.authorVandenesch, F.
dc.contributor.authorSchaumburg, F.
dc.contributor.authorMellmann, A.
dc.date.accessioned2018-08-08T04:43:29Z
dc.date.available2018-08-08T04:43:29Z
dc.date.created2018-08-08T03:50:50Z
dc.date.issued2017
dc.identifier.citationStrauß, L. and Stegger, M. and Akpaka, P. and Alabi, A. and Breurec, S. and Coombs, G. and Egyir, B. et al. 2017. Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8. Proceedings of the National Academy of Sciences of USA. 114 (49): pp. E10596-E10604.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/70109
dc.identifier.doi10.1073/pnas.1702472114
dc.description.abstract

USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary origin of USA300 remained unclear. We used comparative genomics of 224 temporal and spatial diverse S. aureus isolates of multilocus sequence type (ST) 8 to reconstruct the molecular evolution and global dissemination of ST8, including USA300. Analyses of core SNP diversity and accessory genome variations showed that the ancestor of all ST8 S. aureus most likely emerged in Central Europe in the mid-19th century. From here, ST8 was exported to North America in the early 20th century and progressively acquired the USA300 characteristics Panton–Valentine leukocidin (PVL), SCCmec IVa, the arginine catabolic mobile element (ACME), and a specific mutation in capsular polysaccharide gene cap5E. Although the PVL-encoding phage ?Sa2USA was introduced into the ST8 background only once, various SCCmec types were introduced to ST8 at different times and places. Starting from North America, USA300 spread globally, including Africa. African USA300 isolates have aberrant spa-types (t112, t121) and form a monophyletic group within the clade of North American USA300. Large parts of ST8 methicillin-susceptible S. aureus (MSSA) isolated in Africa represent a symplesiomorphic group of ST8 (i.e., a group representing the characteristics of the ancestor), which are rarely found in other world regions. Isolates previously discussed as USA300 ancestors, including USA500 and a “historic” CA-MRSA from Western Australia, were shown to be only distantly related to recent USA300 clones.

dc.publisherNational Academy of Sciences
dc.titleOrigin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8
dc.typeJournal Article
dcterms.source.volume114
dcterms.source.number49
dcterms.source.startPageE10596
dcterms.source.endPageE10604
dcterms.source.issn0027-8424
dcterms.source.titleProceedings of the National Academy of Sciences of USA
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available


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