Pharmaceutical and Biological Evaluation of Nano Photosensitizers for Cancer Therapy
Access Status
Open access
Authors
Sundara Raj, Behin
Date
2018Supervisor
Dr Yan Chen
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
School of Pharmacy and Biomedical Sciences
Collection
Abstract
This study demonstrated the effects of novel hybrid metal oxide nanoparticles as an effective nano-photosensitizer for the photodynamic therapy against melanoma in vitro and in vivo. A strong synergistic effect was produced by the hybrid NPs and UV-A irradiation. The hybrid nanoparticles modified with folic acid enhanced cellular uptake and exhibited strong anti-tumour activity alone and with UV-A. These hybrid nanoparticles provide us better understanding in designing the semiconductor metal oxides-based nano-photosensitizers for photodynamic therapy.
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