Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Determination of human and veterinary antibiotics in indirect potable reuse systems

    146182_23415_busetti and heitz antibiotics 2010 script_1_.pdf (745.3Kb)
    Access Status
    Open access
    Authors
    Busetti, Francesco
    Heitz, Anna
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Busetti, Francesco and Heitz, Anna. 2011. Determination of human and veterinary antibiotics in indirect potable reuse systems. International Journal of Environmental Analytical Chemistry. 91 (10): pp. 989-1012.
    Source Title
    International Journal of Environmental Analytical Chemistry
    DOI
    10.1080/03067310903582374
    ISSN
    03067319
    Faculty
    Department of Applied Chemistry
    School of Science and Computing
    Faculty of Science and Engineering
    Remarks

    This is an Author's version of an article published as: Busetti, Francesco and Heitz, Anna. 2011. Determination of human and veterinary antibiotics in indirect potable reuse systems. International Journal of Environmental Analytical Chemistry. 91 (10): pp. 989-1012 [copyright Taylor & Francis], available online at: www.tandfonline.com

    URI
    http://hdl.handle.net/20.500.11937/7067
    Collection
    • Curtin Research Publications
    Abstract

    This paper reports the optimization and validation of an analytical method for the determination of the residual concentration of the prescription antibiotics metronidazole, trimethoprim, sulfamethoxazole, azithromycin, clindamicyn, clarithromycin, erythromycin-H2O, roxithromycin and tylosin in wastewater and advanced treated wastewater. The method applied was used in a study of removal efficiency of these compounds at a full scale operational water reclamation plant using microfiltration-reverse osmosis (MF-RO) (Kwinana, Western Australia). The analytical procedure involves off-line solid-phase extraction (SPE) followed by liquid chromatography - tandem mass spectrometry (LC-MS/MS) operated in multiple reaction monitoring mode. Method validation included determination of linearity, accuracy, precision, method limits of quantitation (MLQs), reproducibility and matrix effect. SPE recoveries were generally higher than 89% for both pre- and post- RO water, except for erythromycin which yielded approximately 50% recovery. The overall precision of the method was better than 16% RSD (relative standard deviation), for all compounds and matrices. MLQ ranged between 23-53 ng/L and 2.5-31 ng/L for pre- and post- RO water, respectively. In-house reproducibility expressed as RSD was generally better than 10%. Inter-laboratory tests revealed a generally good agreement between concentrations of antibiotics reported by all participants. Results demonstrate that MF/RO treatment is capable of removing antibiotics present at relevant environmental concentration in secondary effluent (from the low to-mid ng/L range) to below MLQs (2.5-31 ng/L), and more importantly, three to six orders of magnitude below the health guideline values developed for this project. Estimated RO rejections ranged between > 91 and 99%.

    Related items

    Showing items related by title, author, creator and subject.

    • Prophylactic Antibiotic Use in Breast Cancer Surgery Patients
      Habak, Jawad; Varma, Sheena; Kianai, M.; Twaddle, A.; Emmerton, Lynne (2013)
      Background: Despite the risks of contributing to antibiotic resistance, guidelines recommend antibiotic prophylaxis for plastic surgery. Aim: To evaluate institutional antibiotic prescribing patterns for breast cancer ...
    • Antibiotic repeat prescriptions: are patients not re-filling them properly?
      Zayegh, Iman; Charrois, Theresa; Hughes, Jeff; Hoti, Kreshnik (2014)
      Objective: This study aimed to explore patients’ utilization of repeat prescriptions for antibiotics indicated in upper respiratory tract infections (URTI). An emphasis was placed on whether the current system of repeat ...
    • Chemoprophylaxis for the prevention of endophthalmitis after cataract surgery: patterns of use and economic costs
      Rosha, Deepinder Singh (2006)
      Objectives: The objectives of study were to (i) examine the regional differences in methods of performing cataract surgery across different jurisdictions in Australia and New Zealand (ii) identify risk factors for ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.