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dc.contributor.authorMooranian, Armin
dc.contributor.supervisorDr Hani Al-Salamien_US
dc.date.accessioned2018-12-04T01:09:31Z
dc.date.available2018-12-04T01:09:31Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/20.500.11937/70687
dc.description.abstract

This thesis studied bile acids in the oral delivery of the anti-diabetic compound probucol as therapy for diabetes mellitus and in the application of microencapsulation of pancreatic β- cells. Bile acids improved the stability of the pharmaceutical formulation system containing probucol and enhanced the oral delivery resulting in greater bioavailability, tissue concentrations and glucose lowering effects in diabetic animals. Bile acids also improved the viability and activity of pancreatic β-cells within microcapsules via cellular protective effects.

en_US
dc.publisherCurtin Universityen_US
dc.titleNovel artificial cell microencapsulation of probucol and bile acids in diabetes mellitusen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentPharmacyen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US


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