Regulation of the brain lipidome in health and disease
Access Status
Open access
Authors
Giles, Corey Steven
Date
2017Supervisor
John Mamo
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
School of Public Health
Curtin Health Innovation Research Institute
Collection
Abstract
This thesis explores the plasma-brain axis in ‘Regulation of the brain lipidome in health and disease’. Using a comprehensive lipidomics platform, the main experimental objectives of this thesis were to investigate the plasma lipidome as a regulator of the cerebral lipidome. Secondary objectives were to explore the potential for therapeutic modulation of sphingolipid metabolism. The experimental findings provide novel insight into regulatory mechanisms, which are informative in the context of neurodegenerative disease processes.
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Giles, C.; Takechi, Ryu; Mellett, N.; Meikle, P.; Dhaliwal, S.; Mamo, John (2016)The brain is highly enriched in lipids, where they influence neurotransmission, synaptic plasticity and inflammation. Non-pathological modulation of the brain lipidome has not been previously reported and few studies have ...