Regulation of the brain lipidome in health and disease
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This thesis explores the plasma-brain axis in ‘Regulation of the brain lipidome in health and disease’. Using a comprehensive lipidomics platform, the main experimental objectives of this thesis were to investigate the plasma lipidome as a regulator of the cerebral lipidome. Secondary objectives were to explore the potential for therapeutic modulation of sphingolipid metabolism. The experimental findings provide novel insight into regulatory mechanisms, which are informative in the context of neurodegenerative disease processes.
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Giles, C.; Takechi, Ryu; Lam, Virginie; Dhaliwal, S.; Mamo, John (2018)Recent advances in analytical techniques have greatly enhanced the depth of coverage, however lipidomic studies are still restricted to analysing only a subset of known lipids. Numerous complementary techniques are used ...
Furse, S.; Liddell, S.; Ortori, C.; Williams, H.; Neylon, Cameron; Scott, D.; Barrett, D.; Gray, D. (2013)In this paper we report the molecular profiling, lipidome and proteome, of the plant organelle known as an oil body (OB). The OB is remarkable in that it is able to perform its biological role (storage of triglycerides) ...
Giles, C.; Takechi, Ryu; Mellett, N.; Meikle, P.; Dhaliwal, S.; Mamo, John (2016)The brain is highly enriched in lipids, where they influence neurotransmission, synaptic plasticity and inflammation. Non-pathological modulation of the brain lipidome has not been previously reported and few studies have ...