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    The effects of long-term saturated fat enriched diets on the brain lipidome

    247174_247174.pdf (3.987Mb)
    Access Status
    Open access
    Authors
    Giles, C.
    Takechi, Ryu
    Mellett, N.
    Meikle, P.
    Dhaliwal, S.
    Mamo, John
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Giles, C. and Takechi, R. and Mellett, N. and Meikle, P. and Dhaliwal, S. and Mamo, J. 2016. The effects of long-term saturated fat enriched diets on the brain lipidome. PLoS One. 11 (12).
    Source Title
    PLoS One
    DOI
    10.1371/journal.pone.0166964
    School
    School of Public Health
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/1064567
    Remarks

    This open access article is distributed under the Creative Commons license https://creativecommons.org/licenses/by/4.0/

    URI
    http://hdl.handle.net/20.500.11937/43135
    Collection
    • Curtin Research Publications
    Abstract

    The brain is highly enriched in lipids, where they influence neurotransmission, synaptic plasticity and inflammation. Non-pathological modulation of the brain lipidome has not been previously reported and few studies have investigated the interplay between plasma lipid homeostasis relative to cerebral lipids. This study explored whether changes in plasma lipids induced by chronic consumption of a well-tolerated diet enriched in saturated fatty acids (SFA) was associated with parallel changes in cerebral lipid homeostasis. Male C57Bl/6 mice were fed regular chow or the SFA diet for six months. Plasma, hippocampus (HPF) and cerebral cortex (CTX) lipids were analysed by LC-ESI-MS/MS. A total of 348 lipid species were determined, comprising 25 lipid classes. The general abundance of HPF and CTX lipids was comparable in SFA fed mice versus controls, despite substantial differences in plasma lipid-class abundance. However, significant differences in 50 specific lipid species were identified as a consequence of SFA treatment, restricted to phosphatidylcholine (PC), phosphatidylethanolamine (PE), alkyl-PC, alkenyl-PC, alkyl-PE, alkenyl-PE, cholesterol ester (CE), diacylglycerol (DG), phosphatidylinositol (PI) and phosphatidylserine (PS) classes. Partial least squares regression of the HPF/CTX lipidome versus plasma lipidome revealed the plasma lipidome could account for a substantial proportion of variation. The findings demonstrate that cerebral abundance of specific lipid species is strongly associated with plasma lipid homeostasis.

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