Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Efficacy of scalp cooling in reducing alopecia in early breast cancer patients receiving contemporary chemotherapy regimens

    Access Status
    Fulltext not available
    Authors
    Chan, Arlene
    Bauwens, A.
    Pontre, S.
    Jackson, S.
    McGlone, F.
    Ernenwein, T.
    Chih, Hui Jun
    Reid, C.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Chan, A. and Bauwens, A. and Pontre, S. and Jackson, S. and McGlone, F. and Ernenwein, T. and Chih, H. et al. 2018. Efficacy of scalp cooling in reducing alopecia in early breast cancer patients receiving contemporary chemotherapy regimens. The Breast. 41: pp. 127-132.
    Source Title
    The Breast
    DOI
    10.1016/j.breast.2018.07.006
    ISSN
    0960-9776
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/70804
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Elsevier Ltd Introduction: Hair loss as a result of chemotherapy for early breast cancer (EBC) is a frequent and distressing side effect. Minimising hair loss may improve mood and body image. Our aim was to determine scalp cooling (SC) efficacy in EBC patients receiving contemporary chemotherapy regimen, to inform future patients choice to use SC or not. Methods and Results: Prospective cohort study of 60 stage 1–3 EBC patients recommended to receive taxane or anthracycline-taxane chemotherapy regimens. The primary outcome was incidence of minimal hair-loss (MHL - defined as 60% Dean grade 1 or 2). Patients were categorised by chemotherapy (3 groups) and randomised 1:1 within each group to two scalp cooling temperature settings using the Dignitana Dignicap machine (secondary endpoint). Patients reported degree of hair loss using the Dean score on day 1 of each cycle and following the last chemotherapy. Results: On an intention-to-treat basis, 33% of patients reported MHL, thus our primary endpoint was not achieved. Patients receiving taxane-only chemotherapy had the highest rate of MHL (45%). No other factors (including hair type, age, body weight, temperature setting) predicted for MHL. Patient-reported anxiety reduced significantly in all patients, but no difference was observed for depression or body image irrespective of degree of hair loss. SC-related adverse events were uniformly of low grade and all resolved. We would recommend the use of SC for all patients receiving taxane-based chemotherapy, with its use for those patients recommended for anthracycline-taxane regimens being made on an individual basis. Trial Registration anztr.org.au ACTRN12615001106527.

    Related items

    Showing items related by title, author, creator and subject.

    • Final Results of the Randomized Phase II NorCap-CA223 Trial Comparing First-Line All-Oral Versus Taxane-Based Chemotherapy for HER2-Negative Metastatic Breast Cancer
      Cinieri, S.; Chan, Arlene; Altundag, K.; Vandebroek, A.; Tubiana-Mathieu, N.; Barnadas, A.; Dodyk, P.; Lazzarelli, S.; Botha, M.; Rauch, D.; Villanova, G.; Coskun, U. (2017)
      © 2016 Elsevier Inc.Background: The purpose of this study was to evaluate the efficacy of 3 first-line chemotherapy combination regimens for HER2-negative metastatic breast cancer (mBC). Patients and Methods: In this ...
    • Comparing neoadjuvant nab-paclitaxel vs paclitaxel both followed by anthracycline regimens in women with ERBB2/ HER2-negative breast cancer-the evaluating treatment with neoadjuvant abraxane (ETNA) trial a randomized phase 3 clinical trial
      Gianni, L.; Mansutti, M.; Anton, A.; Calvo, L.; Bisagni, G.; Bermejo, B.; Semiglazov, V.; Thill, M.; Chacon, J.; Chan, Arlene; Morales, S.; Alvarez, I.; Plazaola, A.; Zambetti, M.; Redfern, A.; Dittrich, C.; Dent, R.; Magazzu, D.; De Fato, R.; Valagussa, P.; Tusquets, I. (2018)
      © 2018 American Medical Association. All rights reserved. IMPORTANCE Studies of neoadjuvant chemotherapy regimens using anthracyclines followed by taxanes have reported a doubling of pathological complete remission (pCR) ...
    • Health-related quality of life with adjuvant docetaxel- and trastuzumab-based regimens in patients with node-positive and high-risk node-negative, her2-positive early breast cancer: Results from the BCIRG 006 study
      Au, H.; Eiermann, W.; Robert, N.; Pienkowski, T.; Crown, J.; Martin, M.; Pawlicki, M.; Chan, Arlene; Mackey, J.; Glaspy, J.; Pintér, T.; Liu, M.; Fornander, T.; Sehdev, S.; Ferrero, J.; Bée, V.; Santana, M.; Miller, D.; Lalla, D.; Slamon, D. (2013)
      Background. This study aims to describe and compare health- related quality of life (HRQL) in patients with node-positive and high-risk node-negative HER2-positive early breast can-cer receiving adjuvant docetaxel and ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.