Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities

    71066.pdf (476.4Kb)
    Access Status
    Open access
    Authors
    Eapen, M.
    Hansbro, P.
    Larsson Callerfelt, A.
    Jolly, M.
    Myers, S.
    Sharma, P.
    Jones, B.
    Rahman, M.
    Markos, J.
    Chia, C.
    Larby, J.
    Haug, G.
    Hardikar, A.
    Weber, H.
    Mabeza, G.
    Cavalheri, Vinicius
    Khor, Y.
    McDonald, C.
    Sohal, S.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Eapen, M. and Hansbro, P. and Larsson Callerfelt, A. and Jolly, M. and Myers, S. and Sharma, P. and Jones, B. et al. 2018. Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities. Drugs. 78 (16): pp. 1717-1740.
    Source Title
    Drugs
    DOI
    10.1007/s40265-018-1001-8
    ISSN
    0012-6667
    School
    School of Physiotherapy and Exercise Science
    Remarks

    The final publication is available at Springer via http://dx.doi.org/10.1007/s40265-018-1001-8

    URI
    http://hdl.handle.net/20.500.11937/70823
    Collection
    • Curtin Research Publications
    Abstract

    Chronic obstructive pulmonary disease (COPD) and lung cancer are major lung diseases affecting millions worldwide. Both diseases have links to cigarette smoking and exert a considerable societal burden. People suffering from COPD are at higher risk of developing lung cancer than those without, and are more susceptible to poor outcomes after diagnosis and treatment. Lung cancer and COPD are closely associated, possibly sharing common traits such as an underlying genetic predisposition, epithelial and endothelial cell plasticity, dysfunctional inflammatory mechanisms including the deposition of excessive extracellular matrix, angiogenesis, susceptibility to DNA damage and cellular mutagenesis. In fact, COPD could be the driving factor for lung cancer, providing a conducive environment that propagates its evolution. In the early stages of smoking, body defences provide a combative immune/oxidative response and DNA repair mechanisms are likely to subdue these changes to a certain extent; however, in patients with COPD with lung cancer the consequences could be devastating, potentially contributing to slower postoperative recovery after lung resection and increased resistance to radiotherapy and chemotherapy. Vital to the development of new-targeted therapies is an in-depth understanding of various molecular mechanisms that are associated with both pathologies. In this comprehensive review, we provide a detailed overview of possible underlying factors that link COPD and lung cancer, and current therapeutic advances from both human and preclinical animal models that can effectively mitigate this unholy relationship.

    Related items

    Showing items related by title, author, creator and subject.

    • Burden of disease and benefits of exercise in fixed airway obstruction asthma
      Turner, Sian Elizabeth (2009)
      Background and research questions. The characterization of chronic persistent asthma in an older adult population is not well defined. This is due to the difficulties in separating the diagnosis of asthma from that of ...
    • Estimating eligibility for lung cancer screening in an Australian cohort, including the effect of spirometry
      Manners, D.; Hui, J.; Hunter, M.; James, A.; Knuiman, M.; McWilliams, A.; Mulrennan, S.; Musk, A.; Brims, Fraser (2016)
      Objectives: To estimate the proportion of ever-smokers who are eligible for lung cancer screening in an Australian cohort, and to evaluate the effect of spirometry in defining chronic obstructive pulmonary disease (COPD) ...
    • COPD-X Australian and New Zealand guidelines for the diagnosis and management of chronic obstructive pulmonary disease: 2017 update
      Yang, I.; Brown, J.; George, J.; Jenkins, Susan; McDonald, C.; McDonald, V.; Phillips, K.; Smith, B.; Zwar, N.; Dabscheck, E. (2017)
      Introduction: Chronic obstructive pulmonary disease (COPD) is characterised by persistent respiratory symptoms and chronic airflow limitation, and is associated with exacerbations and comorbidities. Advances in the ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.