Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

    Access Status
    Fulltext not available
    Authors
    Duke, J.
    Randall, Sean
    Boyd, J.
    Fear, M.
    Rea, S.
    Wood, F.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Duke, J. and Randall, S. and Boyd, J. and Fear, M. and Rea, S. and Wood, F. 2018. A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people. Burns & Trauma. 6.
    Source Title
    Burns & Trauma
    DOI
    10.1186/s41038-018-0120-5
    ISSN
    2321-3868
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/70868
    Collection
    • Curtin Research Publications
    Abstract

    Background: Injury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital admissions data. Methods: A retrospective longitudinal study using linked health data of all patients admitted with burns in Western Australia (n?=?30,997), 1980-2012, and age and gender frequency matched cohorts of people with non-burn trauma (n?=?28,647) and no injury admissions (n?=?123,399). Analyses included direct standardisation, negative binomial regression and Cox proportional hazards regression. Results: Annual age-standardised infectious disease admission rates were highest for the burn cohort, followed by the non-burn trauma and uninjured cohorts. Age-standardised admission rates by decade showed different patterns across major categories of infectious diseases, with the lower respiratory and skin and soft tissue infections the most common for those with burns and other open trauma. Compared with the uninjured, those with burns had twice the admission rate for infectious disease after discharge (incident rate ratio (IRR), 95% confidence interval (CI): 2.04, 1.98-2.11) while non-burn trauma experienced 1.74 times higher rates (95%CI: 1.68-1.81). The burn cohort experienced 10% higher rates of first-time admissions after discharge when compared with the non-burn trauma (hazard ratio (HR), 95%CI: 1.10, 1.05-1.15). Compared with the uninjured cohort, incident admissions were highest during the first 30 days after discharge for burns (HR, 95%CI: 5.18, 4.15-6.48) and non-burn trauma (HR, 95%CI: 5.06, 4.03-6.34). While incident rates remained high over the study period, the magnitude decreased with increasing time from discharge: burn vs uninjured: HR, 95%CI: 30 days to 1 year: 1.69, 1.53-1.87; 1 to 10 years: 1.40, 1.33-1.47; 10 years to end of study period: 1.16, 1.08-1.24; non-burn trauma vs uninjured: HR, 95%CI: 30 days to 1 year: 1.71, 1.55-1.90; 1 to 10 years: 1.30, 1.24-1.37; 10 years to end of study period: 1.09, 1.03-1.17). Conclusions: Burns and non-burn trauma patients had higher admission rates for infectious diseases compared with age and gender matched uninjured people. The pattern of annual admission rates for major categories of infectious diseases varied across injury groups. Overall, the burn cohort experienced the highest rates for digestive, lower respiratory and skin and soft tissue infections. These results suggest long-term vulnerability to infectious disease after injury, possibly related to long-term immune dysfunction.

    Related items

    Showing items related by title, author, creator and subject.

    • Diabetes mellitus after injury in burn and non-burned patients: A population based retrospective cohort study
      Duke, J.; Randall, S.; Fear, M.; Boyd, James; Rea, S.; Wood, F. (2018)
      © 2017 Elsevier Ltd and ISBI. Objective: To compare hospitalisations for diabetes mellitus (DM) after injury experienced by burn patients, non-burn trauma patients and people with no record of injury admission, adjusting ...
    • Long term cardiovascular impacts after burn and non-burn trauma: A comparative population-based study
      Duke, J.; Randall, Sean; Fear, M.; O'Halloran, E.; Boyd, James; Rea, S.; Wood, F. (2017)
      © 2017 Elsevier Ltd and ISBI. Objective: To compare post-injury cardiovascular disease (CVD) hospital admissions experienced by burn patients with non-burn trauma patients and people with no record of injury, adjusting ...
    • Burns and long-term infectious disease morbidity: A population-based study
      Duke, J.; Randall, Sean; Wood, F.; Boyd, James H.; Fear, M. (2016)
      Background: There is a growing volume of data that indicates that serious injury suppresses immune function, predisposing individuals to infectious complications. With recent evidence showing long-term immune dysfunction ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.