Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation

    Access Status
    Open access via publisher
    Authors
    Mincham, K.
    Scott, N.
    Lauzon-Joset, J.
    Leffler, J.
    Larcombe, Alexander
    Stumbles, P.
    Robertson, S.
    Pasquali, C.
    Holt, P.
    Strickland, D.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Mincham, K. and Scott, N. and Lauzon-Joset, J. and Leffler, J. and Larcombe, A. and Stumbles, P. and Robertson, S. et al. 2018. Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation. The Journal of Clinical Investigation. 128 (11): pp. 4856-4869.
    Source Title
    The Journal of Clinical Investigation
    DOI
    10.1172/JCI122631
    ISSN
    1558-8238
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/71166
    Collection
    • Curtin Research Publications
    Abstract

    Chronic allergic inflammatory diseases are a major cause of morbidity, with allergic asthma alone affecting over 300 million people worldwide. Epidemiological studies demonstrate that environmental stimuli are associated with either the promotion or prevention of disease. Major reductions in asthma prevalence are documented in European and US farming communities. Protection is associated with exposure of mothers during pregnancy to microbial breakdown products present in farm dusts and unprocessed foods and enhancement of innate immune competence in the children. We sought to develop a scientific rationale for progressing these findings toward clinical application for primary disease prevention. Treatment of pregnant mice with a defined, clinically approved immune modulator was shown to markedly reduce susceptibility of their offspring to development of the hallmark clinical features of allergic airway inflammatory disease. Mechanistically, offspring displayed enhanced dendritic cell-dependent airway mucosal immune surveillance function, which resulted in more efficient generation of mucosal-homing regulatory T cells in response to local inflammatory challenge. We provide evidence that the principal target for maternal treatment effects was the fetal dendritic cell progenitor compartment, equipping the offspring for accelerated functional maturation of the airway mucosal dendritic cell network following birth. These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention.

    Related items

    Showing items related by title, author, creator and subject.

    • Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease
      Foong, X.; Bosco, A.; Troy, N.; Gorman, S.; Hart, P.; Kicic, Anthony; Zosky, G. (2016)
      © 2016 the American Physiological Society. Vitamin D deficiency is associated with asthma risk. Vitamin D deficiency may enhance the inflammatory response, and we have previously shown that airway remodeling and airway ...
    • 25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life
      Jones, A.; D'Vaz, N.; Meldrum, S.; Palmer, D.; Zhang, Guicheng; Prescott, S. (2015)
      Background: Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies. While immunomodulating properties are well recognized, there are few longitudinal ...
    • DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children
      Stefanowicz, D.; Hackett, T.; Garmaroudi, F.; Günther, O.; Neumann, S.; Sutanto, E.; Ling, K.; Kobor, M.; Kicic, Anthony; Stick, S.; Paré, P.; Knight, D. (2012)
      Background: Allergic inflammation is commonly observed in a number of conditions that are associated with atopy including asthma, eczema and rhinitis. However, the genetic, environmental or epigenetic factors involved in ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.