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    A 4D view on insulin secretory granule turnover in the ß-cell

    Access Status
    Fulltext not available
    Authors
    Müller, A.
    Mziaut, H.
    Neukam, M.
    Knoch, K.
    Solimena, Michele
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Müller, A. and Mziaut, H. and Neukam, M. and Knoch, K. and Solimena, M. 2017. A 4D view on insulin secretory granule turnover in the ß-cell. Diabetes, Obesity and Metabolism. 19: pp. 107-114.
    Source Title
    Diabetes, Obesity and Metabolism
    DOI
    10.1111/dom.13015
    ISSN
    1462-8902
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/71255
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 John Wiley & Sons Ltd Insulin secretory granule (SG) turnover consists of several highly regulated processes allowing for proper ß-cell function and insulin secretion. Besides the spatial distribution of insulin SGs, their age has great impact on the likelihood of their secretion and their behaviour within the ß-cell. While quantitative measurements performed decades ago demonstrated the preferential secretion of young insulin, new experimental approaches aim to investigate insulin ageing at the granular level. Live-cell imaging, automated image analysis and correlative light and electron microscopy have fostered knowledge of age-defined insulin SG dynamics, their interaction with the cytoskeleton and ultrastructural features. Here, we review our recent work in regards to the connection between insulin SG age, SG dynamics, intracellular location and interaction with other proteins.

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