Evidence for the Involvement of the Master Transcription Factor NF-?B in Cancer Initiation and Progression.
MetadataShow full item record
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) is responsible for the regulation of a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. At the same time, this transcription factor can control the expression of a plethora of genes that promote tumor cell proliferation, survival, metastasis, inflammation, invasion, and angiogenesis. The aberrant activation of this transcription factor has been observed in several types of cancer and is known to contribute to aggressive tumor growth and resistance to therapeutic treatment. Although NF-?B has been identified to be a major contributor to cancer initiation and development, there is evidence revealing its role in tumor suppression. This review briefly highlights the major mechanisms of NF-?B activation, the role of NF-?B in tumor promotion and suppression, as well as a few important pharmacological strategies that have been developed to modulate NF-?B function.
Showing items related by title, author, creator and subject.
Gardner, J.; Mamotte, Cyril; Patel, P.; Yeoh, T.; Jackaman, Connie; Nelson, Delia (2015)Dendritic cells (DCs) play an important role in the generation of anti-cancer immune responses, however there is evidence that DCs in cancer patients are dysfunctional. Lipid accumulation driven by tumor-derived factors ...
S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomesKinoshita, R.; Ishima, Y.; Ikeda, M.; Kragh-Hansen, U.; Fang, J.; Nakamura, H.; Chuang, Victor; Tanaka, R.; Maeda, H.; Kodama, A.; Watanabe, H.; Maeda, H.; Otagiri, M.; Maruyama, T. (2015)© 2015 Elsevier B.V. All rights reserved. The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors, and it can serve as a basis for the development of macromolecular anticancer therapy. ...
Rapid copper acquisition by developing murine mesothelioma: Decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltrationCrowe, Andrew; Jackaman, Connie; Beddoes, Katie; Ricciardo, Belinda; Nelson, Delia (2013)Copper, an essential trace element acquired through nutrition, is an important co-factor for pro-angiogenic factors including vascular endothelial growth factor (VEGF). Decreasing bioavailable copper has been used as an ...