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    Evidence for the Involvement of the Master Transcription Factor NF-?B in Cancer Initiation and Progression.

    Access Status
    Fulltext not available
    Authors
    Puar, Y.
    Shanmugam, M.
    Fan, L.
    Arfuso, Frank
    Sethi, G.
    Tergaonkar, V.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Puar, Y. and Shanmugam, M. and Fan, L. and Arfuso, F. and Sethi, G. and Tergaonkar, V. 2018. Evidence for the Involvement of the Master Transcription Factor NF-?B in Cancer Initiation and Progression.. Biomedicines. 6 (3).
    Source Title
    Biomedicines
    DOI
    10.3390/biomedicines6030082
    ISSN
    2227-9059
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/71322
    Collection
    • Curtin Research Publications
    Abstract

    Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) is responsible for the regulation of a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. At the same time, this transcription factor can control the expression of a plethora of genes that promote tumor cell proliferation, survival, metastasis, inflammation, invasion, and angiogenesis. The aberrant activation of this transcription factor has been observed in several types of cancer and is known to contribute to aggressive tumor growth and resistance to therapeutic treatment. Although NF-?B has been identified to be a major contributor to cancer initiation and development, there is evidence revealing its role in tumor suppression. This review briefly highlights the major mechanisms of NF-?B activation, the role of NF-?B in tumor promotion and suppression, as well as a few important pharmacological strategies that have been developed to modulate NF-?B function.

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