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    The regenerative potential of epithelial stem cells in tissue repair

    Access Status
    Fulltext not available
    Authors
    Arandjelovic, P.
    Kaur, Pritinder
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Arandjelovic, P. and Kaur, P. 2014. The regenerative potential of epithelial stem cells in tissue repair. International Journal of Biochemistry and Cell Biology. 56: pp. 107-110.
    Source Title
    International Journal of Biochemistry and Cell Biology
    DOI
    10.1016/j.biocel.2014.10.017
    ISSN
    1357-2725
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/71535
    Collection
    • Curtin Research Publications
    Abstract

    © 2014 Elsevier Ltd. Acute and chronic wounds encompass devastating injuries with significant physical, emotional and economic costs at both the individual and societal level. The pathogenesis of chronic wounds is as varied as the potential causes; however, contributing factors include repetitive ischaemia/reperfusion injury coupled with bacterial infection, inflammation and matrix degradation at the wound site. Similarly, the acute physical damage of burns may leave patients vulnerable to dehydration and infection, and in certain cases this may be followed by a body-wide systemic response with debilitating consequences. Epithelial stem cells provide a promising avenue for the treatment of burns and chronic wounds. This is exemplified by recent achievements such as the restoration of corneal epithelium using limbal stem cells, and the treatment of epidermolysis bullosa via a gene therapy approach. Nevertheless, many technical and regulatory challenges remain to be addressed. This article is part of a Directed Issue entitled: Regenerative Medicine: the challenge of translation.

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