Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Evidence of Heritable Determinants of Decompression Sickness in Rats

    Access Status
    Fulltext not available
    Authors
    Lautridou, J.
    Buzzacott, Peter
    Belhomme, M.
    Dugrenot, E.
    Lafère, P.
    Balestra, C.
    Guerrero, F.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Lautridou, J. and Buzzacott, P. and Belhomme, M. and Dugrenot, E. and Lafère, P. and Balestra, C. and Guerrero, F. 2017. Evidence of Heritable Determinants of Decompression Sickness in Rats. Medicine and Science in Sports and Exercise. 49 (12): pp. 2433-2438.
    Source Title
    Medicine and Science in Sports and Exercise
    DOI
    10.1249/MSS.0000000000001385
    ISSN
    0195-9131
    School
    School of Nursing, Midwifery and Paramedicine
    URI
    http://hdl.handle.net/20.500.11937/71543
    Collection
    • Curtin Research Publications
    Abstract

    Introduction Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation after a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the interindividual variability of DCS occurrence. This study aimed to experimentally assess the existence of heritable factors involved in DCS occurrence by selectively breeding individuals resistant to DCS from a population stock of Wistar rats. Methods Fifty-two male and 52 female Wistar rats were submitted to a simulated air dive known to reliably induce about 63% DCS: compression was performed at 100 kPa·min-1up to 1000 kPa absolute pressure before a 45-min long stay. Decompression was performed at 100 kPa·min-1with three decompression stops: 5 min at 200 kPa, 5 min at 160 kPa, and 10 min at 130 kPa. Animals were observed for 1 h to detect DCS symptoms. Individuals without DCS were selected and bred to create a new generation, subsequently subjected to the same hyperbaric protocol. This procedure was repeated up to the third generation of rats. Results As reported previously, this diving profile induced 67% of DCS, and 33% asymptomatic animals in the founding population. DCS/asymptomatic ratio was not initially different between sexes, although males were heavier than females. In three generations, the outcome of the dive significantly changed from 33% to 67% asymptomatic rats, for both sexes. Interestingly, survival in females increased sooner than in males. Conclusions This study offers evidence suggesting the inheritance of DCS resistance. Future research will focus on genetic and physiological comparisons between the initial strain and the new resistant population.

    Related items

    Showing items related by title, author, creator and subject.

    • Endothelial dysfunction correlates with decompression bubbles in rats
      Zhang, K.; Wang, D.; Jiang, Z.; Ning, X.; Buzzacott, Peter; Xu, W. (2016)
      © 2016 The Author(s). Previous studies have documented that decompression led to endothelial dysfunction with controversial results. This study aimed to clarify the relationship between endothelial dysfunction, bubble ...
    • Early decompression following cervical spinal cord injury: examining the process of care from accident scene to surgery
      Battistuzzo, C.; Armstrong, A.; Clark, J.; Worley, L.; Sharwood, L.; Lin, P.; Rooke, G.; Skeers, P.; Nolan, S.; Geragthy, T.; Nunn, A.; Brown, D.; Hill, S.; Alexander, J.; Millard, M.; Cox, S.; Rao, S.; Watts, A.; Goods, L.; Allison, Garry; Laurenson, J.; Cameron, P.; Mosley, I.; Liew, S.; Geddes, T.; Middleton, J.; Buchanan, J.; Rosenfeld, J.; Bernard, S.; Atresh, S.; Patel, A.; Schouten, R.; Freeman, B.; Dunlop, S.; Batchelor, P. (2015)
      Early decompression may improve neurological outcome after spinal cord injury (SCI), but is often difficult to achieve because of logistical issues. The aims of this study were to determine (1) the time to decompression ...
    • Time course of endothelial dysfunction induced by decompression bubbles in rats
      Zhang, K.; Wang, M.; Wang, H.; Liu, Y.; Buzzacott, Peter; Xu, W. (2017)
      © 2017 Zhang, Wang, Wang, Liu, Buzzacott and Xu. Decompression stress can cause endothelial injury, leading to systematic inflammation and prothrombotic phenomena. Our previous work found that endothelial injury following ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.