Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Costs and outcomes of Lynch syndrome screening in the Australian colorectal cancer population

    Access Status
    Fulltext not available
    Authors
    Cenin, Dayna
    Naber, S.
    Lansdorp-Vogelaar, Iris
    Jenkins, M.
    Buchanan, D.
    Preen, D.
    Ee, H.
    O'Leary, Peter
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Cenin, D. and Naber, S. and Lansdorp-Vogelaar, I. and Jenkins, M. and Buchanan, D. and Preen, D. and Ee, H. et al. 2018. Costs and outcomes of Lynch syndrome screening in the Australian colorectal cancer population. Journal of Gastroenterology and Hepatology. 33 (10): pp. 1737-1744.
    Source Title
    Journal of Gastroenterology and Hepatology
    DOI
    10.1111/jgh.14154
    ISSN
    0815-9319
    School
    Health Sciences Research and Graduate Studies
    URI
    http://hdl.handle.net/20.500.11937/71547
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 The Authors Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: Individuals with Lynch syndrome (LS) are at increased risk of LS-related cancers including colorectal cancer (CRC). CRC tumor screening for mismatch repair (MMR) deficiency is recommended in Australia to identify LS, although its cost-effectiveness has not been assessed. We aim to determine the cost-effectiveness of screening individuals with CRC for LS at different age-at-diagnosis thresholds. Methods: We developed a decision analysis model to estimate yield and costs of LS screening. Age-specific probabilities of LS diagnosis were based on Australian data. Two CRC tumor screening pathways were assessed (MMR immunohistochemistry followed by MLH1 methylation (MLH1-Pathway) or BRAF V600E testing (BRAF-Pathway) if MLH1 expression was lost) for four age-at-diagnosis thresholds—screening < 50, screening < 60, screening < 70, and universal screening. Results: Per 1000 CRC cases, screening < 50 identified 5.2 LS cases and cost $A7041 per case detected in the MLH1-Pathway. Screening < 60 increased detection by 1.5 cases for an incremental cost of $A25 177 per additional case detected. Screening < 70 detected 1.6 additional cases at an incremental cost of $A40 278 per additional case detected. Compared with screening < 70, universal screening detected no additional LS cases but cost $A158 724 extra. The BRAF-Pathway identified the same number of LS cases for higher costs. Conclusions: The MLH1-Pathway is more cost-effective than BRAF-Pathway for all age-at-diagnosis thresholds. MMR immunohistochemistry tumor screening in individuals diagnosed with CRC aged < 70 years resulted in higher LS case detection at a reasonable cost. Further research into the yield of LS screening in CRC patients = 70 years is needed to determine if universal screening is justified.

    Related items

    Showing items related by title, author, creator and subject.

    • Long-term evaluation of benefits, harms, and cost-effectiveness of the National Bowel Cancer Screening Program in Australia: a modelling study
      Lew, J.; St John, D.; Xu, X.; Greuter, M.; Caruana, M.; Cenin, Dayna; He, E.; Saville, M.; Grogan, P.; Coupé, V.; Canfell, K. (2017)
      © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Background No assessment of the National Bowel Screening Program (NBCSP) in Australia, which considers all ...
    • Characterisation of aquatic natural organic matter by micro-scale sealed vessel pyrolysis
      Berwick, Lyndon (2009)
      The analytical capacity of MSSV pyrolysis has been used to extend the structural characterisation of aquatic natural organic matter (NOM). NOM can contribute to various potable water issues and is present in high ...
    • Cost Effectiveness of Screening Patients With Gastroesophageal Reflux Disease for Barrett's Esophagus With a Minimally Invasive Cell Sampling Device
      Heberle, C.; Omidvari, A.; Ali, A.; Kroep, S.; Kong, C.; Inadomi, J.; Rubenstein, J.; Tramontano, A.; Dowling, E.; Hazelton, W.; Luebeck, E.; Lansdorp-Vogelaar, Iris; Hur, C. (2017)
      Background & Aims: It is important to identify patients with Barrett's esophagus (BE), the precursor to esophageal adenocarcinoma (EAC). Patients with BE usually are identified by endoscopy, which is expensive. The ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.