Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles

Liang, X.; Wang, H.; Grice, J.; Li, L.; Liu, Jian; Xu, Z.; Roberts, M.

doi:10.1021/acs.nanolett.5b03854

Access Status

Fulltext not available

Authors

Liang, X.

Wang, H.

Grice, J.

Li, L.

Liu, Jian

Xu, Z.

Roberts, M.

Date

2016

Type

Journal Article

Metadata

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Citation

Liang, X. and Wang, H. and Grice, J. and Li, L. and Liu, J. and Xu, Z. and Roberts, M. 2016. Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles. Nano Letters: a journal dedicated to nanoscience and nanotechnology. 16 (2): pp. 939-945.

Source Title

Nano Letters: a journal dedicated to nanoscience and nanotechnology

DOI

10.1021/acs.nanolett.5b03854

ISSN

1530-6984

School

WASM: Minerals, Energy and Chemical Engineering (WASM-MECE)

URI

http://hdl.handle.net/20.500.11937/71707

Collection

Curtin Research Publications

Abstract

© 2016 American Chemical Society. A physiologically based pharmacokinetic model was developed for accurately characterizing and predicting the in vivo fate of long-circulating inorganic nanoparticles (NPs). This model is built based on direct visualization of NP disposition details at the organ and cellular level. It was validated with multiple data sets, indicating robust inter-route and interspecies predictive capability. We suggest that the biodistribution of long-circulating inorganic NPs is determined by the uptake and release of NPs by phagocytic cells in target organs.