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    An investigation of a vitamin D, ionised calcium and parathyroid hormone regulatory axis of cerebral capillary function: Implications for cognitive performance in ageing

    242460_Lam V 2015.pdf (47.61Mb)
    Access Status
    Open access
    Authors
    Lam, Virginie
    Date
    2015
    Supervisor
    Prof. Satvinder Dhaliwal
    Prof. John Mamo
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/718
    Collection
    • Curtin Theses
    Abstract

    Increasing evidence suggests compromised integrity of cerebral capillary endothelium precedes cognitive impairment and the onset of Alzheimer’s disease and vascular dementia. Results from in vivo animal model studies demonstrated novel findings of potential detrimental effects of hypervitaminosis D on cerebral capillary integrity. Verbal episodic memory performance was negatively associated with vitamin D homeostasis in healthy older-aged adults. Overall, the use of vitamin D (VD) supplements should be considered only in context of VD deficiency.

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    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.