An investigation of a vitamin D, ionised calcium and parathyroid hormone regulatory axis of cerebral capillary function: Implications for cognitive performance in ageing

Abstract

Increasing evidence suggests compromised integrity of cerebral capillary endothelium precedes cognitive impairment and the onset of Alzheimer’s disease and vascular dementia. Results from in vivo animal model studies demonstrated novel findings of potential detrimental effects of hypervitaminosis D on cerebral capillary integrity. Verbal episodic memory performance was negatively associated with vitamin D homeostasis in healthy older-aged adults. Overall, the use of vitamin D (VD) supplements should be considered only in context of VD deficiency.