Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration
MetadataShow full item record
© 2018 2018 Newlands Press. Aim: To enhance the bioavailability and brain uptake of probucol and examine whether it attenuates neuroinflammation and neurodegeneration by utilizing a sodium alginate nanoencapsulation technique. Materials & methods: Wild-type mice were given either low-fat standard chow, high-fat (HF) diet to induce neuroinflammation and neurodegeneration, HF diet supplemented with nanocapsuled probucol at a concentration of 0.1% (w/w), HF diet supplemented with noncapsulated probucol at the same concentration of 0.1%, or HF diet supplemented with noncapsulated probucol at higher concentration (1%) for 24 weeks. Results & conclusion: The nanoencapsulation increased the plasma and brain concentration of probucol significantly compared with the mice that was given the same dosage of probucol without capsulation, and significantly suppressed the neuroinflammation and neurodegeneration.
Showing items related by title, author, creator and subject.
Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic dietMamo, John; Lam, Virginie; Brook, E.; Mooranian, A.; Al-Salami, Hani; Fimognari, N.; Nesbit, M.; Takechi, Ryu (2018)© The Author(s) 2018. An emerging body of evidence consistently suggests that compromised blood–brain barrier integrity may be causally associated with cognitive decline induced by type-2 diabetes. Our previous studies ...
Pallebage-Gamarallage, Menuka Madhavi Somapala (2012)Alzheimer’s disease (AD) is the most common cause of dementia pathologically characterised by neurovascular inflammation, extracellular proteinaceous deposits enriched in amyloid-β (Aβ) and formation of neurofibrillar ...
Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: An implication for causal linkTakechi, Ryu; Lam, Virginie; Brook, Emily; Giles, Corey; Fimognari, Nicholas; Mooranian, Armin; Al-Salami, Hani; Coulson, Stephanie; Nesbit, Michael; Mamo, John (2017)© 2017 Takechi, Lam, Brook, Giles, Fimognari, Mooranian, Al-Salami, Coulson, Nesbit and Mamo. Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk through unknown mechanisms. Emerging ...