Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Effect of simulated air dive and decompression sickness on the plasma proteome of rats

    Access Status
    Fulltext not available
    Authors
    Lautridou, J.
    Pichereau, V.
    Artigaud, S.
    Buzzacott, Peter
    Wang, Q.
    Bernay, B.
    Driad, S.
    Mazur, A.
    Lambrechts, K.
    Théron, M.
    Guerrero, F.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Lautridou, J. and Pichereau, V. and Artigaud, S. and Buzzacott, P. and Wang, Q. and Bernay, B. and Driad, S. et al. 2016. Effect of simulated air dive and decompression sickness on the plasma proteome of rats. Proteomics - Clinical Applications. 10 (5): pp. 614-620.
    Source Title
    Proteomics - Clinical Applications
    DOI
    10.1002/prca.201600017
    ISSN
    1862-8346
    School
    School of Nursing, Midwifery and Paramedicine
    URI
    http://hdl.handle.net/20.500.11937/71813
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Purpose: Decompression sickness (DCS) is a poorly understood systemic disease caused by inadequate desaturation following a reduction in ambient pressure. Although recent studies highlight the importance of circulating factors, the available data are still puzzling. In this study, we aimed to identify proteins and biological pathways involved in the development of DCS in rats. Experimental design: Eighteen male Sprague-Dawley rats were subjected to a same simulated air dive to 1000 kPa absolute pressure and divided into two groups: no DCS or DCS. A third control group remained at atmospheric pressure. Venous blood was collected after hyperbaric exposure and the plasma proteomes from four individuals per group were analyzed by using a two-dimensional electrophoresis-based proteomic strategy. Results: Quantitative analysis identified nine protein spots with abundances significantly changed (false discovery rate < 0.1) between the tested conditions. Three protein spots, identified as Apolipoprotein A1, Serine Protease Inhibitor A3K (Serpin A3K), and Alpha-1-antiproteinase, appeared increased in DCS animals but displayed only weak changes. By contrast, one protein spot identified as Transthyretin (TTR) dramatically decreased (i.e. quite disappeared) in animals displaying DCS symptoms. Before diving, TTR level was not different in DCS than nondiving group. Conclusion: These results may lead to the use of TTR as an early biomarker of DCS.

    Related items

    Showing items related by title, author, creator and subject.

    • A randomised controlled trial of twelve months protein supplementation on muscle mass and strength in elderly women
      Meng, Xingqiong (Rosie) (2010)
      Background. Aging is associated with progressive loss of muscle (sarcopenia), which can lead to reduced muscle strength and an increased risk of falls. Sarcopenia exists in otherwise healthy elderly people and its aetiology ...
    • Disruption of blood-brain barrier function by chronic intake of saturated fat and cholesterol : implications for Alzheimer’s disease risk
      Takechi, Ryusuke (2010)
      It has been reported that lifestyle including diet is associated with Alzheimer’s disease (AD) risk and progression. Population studies indicate that the chronic consumption of diets enriched in saturated fats (SFA) and ...
    • Molecular modelling of the interactions of complex carbohydrates with proteins
      Gandhi, Neha Sureshchandra (2011)
      Glycosaminoglycans (GAGs) are ubiquitous complex carbohydrate molecules present on the cell surfaces and in extracellular matrices (ECM) of vertebrate and invertebrate tissues. The interactions of sulphated GAGs such as ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.