A brief history of blood platelets: A personal view
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© Springer International Publishing AG 2017. A search on 'platelets' in Pubmed yields more than 100,000 publications indicating both the depth and interest. Platelets are small anucleate cells that circulate freely in the vasculature. In haemostasis, they adhere rapidly, become activated, spread and coat the damaged vasculature. Our understanding of platelet structure and function has advanced in waves, dependent upon the development of the next cutting-edge technology. This brief chapter describes the key historical events leading to our current understanding of platelet structure and function.
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Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histonesElaskalani, O.; Abdol Razak, N.; Metharom, Pat (2018)© 2018 The Author(s). Background: The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens. Recently ...
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Masselli, E.; Pozzi, G.; Vaccarezza, Mauro ; Mirandola, P.; Galli, D.; Vitale, M.; Carubbi, C.; Gobbi, G. (2020)© 2020 by the authors. Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet functions. Platelet activation determines a drastic change in redox balance and in platelet metabolism. ...