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    Brinp1 -/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

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    Fulltext not available
    Authors
    Berkowicz, S.
    Featherby, T.
    Qu, Z.
    Giousoh, A.
    Borg, N.
    Heng, Julian
    Whisstock, J.
    Bird, P.
    Date
    2016
    Type
    Journal Article
    
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    Citation
    Berkowicz, S. and Featherby, T. and Qu, Z. and Giousoh, A. and Borg, N. and Heng, J. and Whisstock, J. et al. 2016. Brinp1 -/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density. Molecular Autism. 7 (1).
    Source Title
    Molecular Autism
    DOI
    10.1186/s13229-016-0079-7
    ISSN
    2040-2392
    School
    Health Sciences Research and Graduate Studies
    URI
    http://hdl.handle.net/20.500.11937/71925
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 Berkowicz et al. Background: BMP/RA-inducible neural-specific protein 1 (Brinp1) is highly conserved in vertebrates, and continuously expressed in the neocortex, hippocampus, olfactory bulb and cerebellum from mid-embryonic development through to adulthood. Methods: Brinp1 knock-out (Brinp1 -/-) mice were generated by Cre-recombinase-mediated removal of the third exon of Brinp1. Knock-out mice were characterised by behavioural phenotyping, immunohistochemistry and expression analysis of the developing and adult brain. Results: Absence of Brinp1 during development results in a behavioural phenotype resembling autism spectrum disorder (ASD), in which knock-out mice show reduced sociability and changes in vocalisation capacity. In addition, Brinp1 -/- mice exhibit hyper-locomotor activity, have impaired short-term memory, and exhibit poor reproductive success. Brinp1 -/- mice show increased density of parvalbumin-expressing interneurons in the adult mouse brain. Brinp1 -/- mice do not show signs of altered neural precursor proliferation or increased apoptosis during late embryonic brain development. The expression of the related neuronal migration genes Astn1 and Astn2 is increased in the brains of Brinp1 -/- mice, suggesting that they may ameliorate the effects of Brinp1 loss. Conclusions: Brinp1 plays an important role in normal brain development and function by influencing neuronal distribution within the cortex. The increased cortical PV-positive interneuron density and altered behaviour of Brinp1 -/- mice resemble features of a subset of human neurological disorders; namely autism spectrum disorder (ASD) and the hyperactivity aspect of attention deficit hyperactivity disorder (ADHD).

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