Show simple item record

dc.contributor.authorMérarchi, M.
dc.contributor.authorSethi, G.
dc.contributor.authorFan, L.
dc.contributor.authorMishra, S.
dc.contributor.authorArfuso, Frank
dc.contributor.authorAhn, K.
dc.date.accessioned2018-12-13T09:12:03Z
dc.date.available2018-12-13T09:12:03Z
dc.date.created2018-12-12T02:47:06Z
dc.date.issued2018
dc.identifier.citationMérarchi, M. and Sethi, G. and Fan, L. and Mishra, S. and Arfuso, F. and Ahn, K. 2018. Molecular targets modulated by fangchinoline in tumor cells and preclinical models. Molecules. 23 (10): 2538.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/72007
dc.identifier.doi10.3390/molecules23102538
dc.description.abstract

© 2018 MDPI AG. All rights reserved. Despite tremendous progress made during the last few decades in the treatment options for cancer, compounds isolated from Mother Nature remain the mainstay for therapy of various malignancies. Fangchinoline, initially isolated from the dried root of Stephaniae tetrandrine, has been found to exhibit diverse pharmacological effects including significant anticancer activities both in tumor cell lines and selected preclinical models. This alkaloid appears to act by modulating the activation of various important oncogenic molecules involved in tumorigenesis leading to a significant decrease in aberrant proliferation, survival and metastasis of tumor cells. This mini-review briefly describes the potential effects of fangchinoline on important hallmarks of cancer and highlights the molecular targets modulated by this alkaloid in various tumor cell lines and preclinical models.

dc.publisherM D P I AG
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleMolecular targets modulated by fangchinoline in tumor cells and preclinical models
dc.typeJournal Article
dcterms.source.volume23
dcterms.source.number10
dcterms.source.issn1420-3049
dcterms.source.titleMolecules
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/