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    Organochlorine Levels in Plasma and Risk of Multiple Myeloma

    Access Status
    Fulltext not available
    Authors
    Weber, L.
    Song, K.
    Boyle, Terry
    Gaudreau, �.
    Lai, A.
    Sutherland, H.
    LeBlanc, A.
    Spinelli, J.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Weber, L. and Song, K. and Boyle, T. and Gaudreau, �. and Lai, A. and Sutherland, H. and LeBlanc, A. et al. 2018. Organochlorine Levels in Plasma and Risk of Multiple Myeloma. J Occup Environ Med. 60 (10): pp. 911-916.
    Source Title
    J Occup Environ Med
    DOI
    10.1097/JOM.0000000000001387
    ISSN
    1536-5948
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/72196
    Collection
    • Curtin Research Publications
    Abstract

    CONCLUSION: Our study provides evidence that organochlorines contribute to the risk of MM.RESULTS: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio?=?7.44; 95% confidence interval?=?4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and ß-hexachlorocyclohexane (ß-HCCH) were identified as significant independent predictors of MM.OBJECTIVE: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM).METHODS: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls.

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