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Organochlorine Levels in Plasma and Risk of Multiple Myeloma

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Authors
Weber, L.
Song, K.
Boyle, Terry
Gaudreau, �.
Lai, A.
Sutherland, H.
LeBlanc, A.
Spinelli, J.
Date
2018
Type
Journal Article

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Weber, L. and Song, K. and Boyle, T. and Gaudreau, �. and Lai, A. and Sutherland, H. and LeBlanc, A. et al. 2018. Organochlorine Levels in Plasma and Risk of Multiple Myeloma. J Occup Environ Med. 60 (10): pp. 911-916.
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J Occup Environ Med
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School of Public Health
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Abstract

CONCLUSION: Our study provides evidence that organochlorines contribute to the risk of MM.RESULTS: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio?=?7.44; 95% confidence interval?=?4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and ß-hexachlorocyclohexane (ß-HCCH) were identified as significant independent predictors of MM.OBJECTIVE: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM).METHODS: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls.