Show simple item record

dc.contributor.authorHallstrand, T.
dc.contributor.authorLeuppi, J.
dc.contributor.authorJoos, G.
dc.contributor.authorHall, Graham
dc.contributor.authorCarlsen, K.
dc.contributor.authorKaminsky, D.
dc.contributor.authorCoates, A.
dc.contributor.authorCockcroft, D.
dc.contributor.authorCulver, B.
dc.contributor.authorDiamant, Z.
dc.contributor.authorGauvreau, G.
dc.contributor.authorHorvath, I.
dc.contributor.authorde Jongh, F.
dc.contributor.authorLaube, B.
dc.contributor.authorSterk, P.
dc.contributor.authorWanger, J.
dc.date.accessioned2018-12-13T09:13:12Z
dc.date.available2018-12-13T09:13:12Z
dc.date.created2018-12-12T02:46:27Z
dc.date.issued2018
dc.identifier.citationHallstrand, T. and Leuppi, J. and Joos, G. and Hall, G. and Carlsen, K. and Kaminsky, D. and Coates, A. et al. 2018. ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. The European respiratory journal. 52 (5).
dc.identifier.urihttp://hdl.handle.net/20.500.11937/72357
dc.identifier.doi10.1183/13993003.01033-2018
dc.description.abstract

Copyright ©ERS 2018. Recently, this international task force reported the general considerations for bronchial challenge testing and the performance of the methacholine challenge test, a "direct" airway challenge test. Here, the task force provides an updated description of the pathophysiology and the methods to conduct indirect challenge tests. Because indirect challenge tests trigger airway narrowing through the activation of endogenous pathways that are involved in asthma, indirect challenge tests tend to be specific for asthma and reveal much about the biology of asthma, but may be less sensitive than direct tests for the detection of airway hyperresponsiveness. We provide recommendations for the conduct and interpretation of hyperpnoea challenge tests such as dry air exercise challenge and eucapnic voluntary hyperpnoea that provide a single strong stimulus for airway narrowing. This technical standard expands the recommendations to additional indirect tests such as hypertonic saline, mannitol and adenosine challenge that are incremental tests, but still retain characteristics of other indirect challenges. Assessment of airway hyperresponsiveness, with direct and indirect tests, are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy. The tests should be interpreted within the context of the clinical features of asthma.

dc.titleERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing
dc.typeJournal Article
dcterms.source.volume52
dcterms.source.number5
dcterms.source.issn1399-3003
dcterms.source.titleThe European respiratory journal
curtin.departmentSchool of Physiotherapy and Exercise Science
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record