Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility

Teng, W. and Wang, J. and Foster, N. and Wen, N. and Zhang, J. 2014. Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility. Industrial and Engineering Chemistry Research. 53 (26): pp. 10519-10524.

Source Title

Industrial and Engineering Chemistry Research

DOI

10.1021/ie501147f

ISSN

0888-5885

School

WASM: Minerals, Energy and Chemical Engineering (WASM-MECE)

URI

http://hdl.handle.net/20.500.11937/72404

Collection

Curtin Research Publications

Abstract

Silybin (SLB), a kind of antihepatotoxic polyphenolic substance, is currently available for a variety of acute and chronic liver diseases. However, its poor solubility and low bioavailability have strongly limited its therapeutic applications. In this work, we demonstrate a simple solution to address these issues by designing SLB/poly(vinylpyrrolidone) (PVP) nanodrugs via the aerosol solvent extraction system (ASES). In the ASES process, SLB and PVP are prepared via coprecipitation by using the dimethylformamide/dense gas CO2solvent/antisolvent strategy. The size of the as-obtained SLB/PVP nanodrugs (denoted as NanoSLB) can be tuned from 100 to 300 nm. Compared with raw SLB, NanoSLB is of low crystallinity and hence shows drug solubility greatly enhanced by more than 8-fold. This work will broaden the applications of water-insoluble drugs in pharmaceutical treatments. © 2014 American Chemical Society.