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    Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility

    Access Status
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    Authors
    Teng, W.
    Wang, J.
    Foster, Neil
    Wen, N.
    Zhang, J.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Teng, W. and Wang, J. and Foster, N. and Wen, N. and Zhang, J. 2014. Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility. Industrial and Engineering Chemistry Research. 53 (26): pp. 10519-10524.
    Source Title
    Industrial and Engineering Chemistry Research
    DOI
    10.1021/ie501147f
    ISSN
    0888-5885
    School
    WASM: Minerals, Energy and Chemical Engineering (WASM-MECE)
    URI
    http://hdl.handle.net/20.500.11937/72404
    Collection
    • Curtin Research Publications
    Abstract

    Silybin (SLB), a kind of antihepatotoxic polyphenolic substance, is currently available for a variety of acute and chronic liver diseases. However, its poor solubility and low bioavailability have strongly limited its therapeutic applications. In this work, we demonstrate a simple solution to address these issues by designing SLB/poly(vinylpyrrolidone) (PVP) nanodrugs via the aerosol solvent extraction system (ASES). In the ASES process, SLB and PVP are prepared via coprecipitation by using the dimethylformamide/dense gas CO2solvent/antisolvent strategy. The size of the as-obtained SLB/PVP nanodrugs (denoted as NanoSLB) can be tuned from 100 to 300 nm. Compared with raw SLB, NanoSLB is of low crystallinity and hence shows drug solubility greatly enhanced by more than 8-fold. This work will broaden the applications of water-insoluble drugs in pharmaceutical treatments. © 2014 American Chemical Society.

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