Smart pH-responsive nanocarriers based on nano-graphene oxide for combined chemo- and photothermal therapy overcoming drug resistance
MetadataShow full item record
A pH-responsive nanocarrier is developed by coating nanoscale graphene oxide (NGO) with dual types of polymers, polyethylene glycol (PEG) and poly(allylamine hydrochloride) (PAH), the latter of which is then modified with 2,3-dimethylmaleic anhydride (DA) to acquire pH-dependent charge reversibility. After loading with doxorubicin (DOX), a chemotherapy drug, the obtained NGO-PEG-DA/DOX complex exhibits a dual pH-responsiveness, showing markedly enhanced cellular uptake under the tumor microenvironmental pH, and accelerated DOX release under a further lowered pH inside cell lysosomes. Combining such a unique behavior with subsequently slow efflux of DOX, NGO-PEG-DA/DOX offers remarkably improved cell killing for drug-resistant cancer cells under the tumor microenvironmental pH in comparison with free DOX. Exploiting its excellent photothermal conversion ability, combined chemo- and photothermal therapy is further demonstrated using NGO-PEG-DA/DOX, realizing a synergistic therapeutic effect. This work presents a novel design of surface chemistry on NGO for the development of smart drug delivery systems responding to the tumor microenvironment and external physical stimulus, with the potential to overcome drug resistance. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Showing items related by title, author, creator and subject.
Exploring the micro-politics of normalised drug use in the social lives of a group of young 'party drug' users in Melbourne, AustraliaPennay, Amy (2012)Young people today live in what some scholars and commentators have defined as a 'post-modern' era, characterised by globalisation, the internet, mass media, production and consumption. Post-modernity has seen a change ...
An ethnographic study of recreational drug use and identity management among a network of electronic dance music enthusiasts in Perth, Western AustraliaGreen, Rachael Renee (2012)This thesis explores the social contexts and cultural significance of amphetamine-type stimulant (ATS) and alcohol use among a social network of young adults in Perth, Western Australia. The study is positioned by the ...
Repeat Adverse Drug Reaction-Related Hospital Admissions in Elderly Australians: A Retrospective Study at the Royal Hobart HospitalParameswaran Nair, N.; Stafford, Leanne; Bereznicki, B.; Curtain, C.; Bereznicki, L. (2017)© 2017, Springer International Publishing AG. Background: Adverse drug reactions are a major cause of hospital admissions in older individuals, with the majority potentially preventable. Despite the apparent magnitude of ...