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    Peptides for biopharmaceutical applications

    Access Status
    Fulltext not available
    Authors
    Agyei, D.
    Tan, K.
    Pan, S.
    Udenigwe, C.
    Danquah, Michael
    Date
    2018
    Type
    Book Chapter
    
    Metadata
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    Citation
    Agyei, D. and Tan, K. and Pan, S. and Udenigwe, C. and Danquah, M. 2018. Peptides for biopharmaceutical applications. In Peptide Applications in Biomedicine, Biotechnology and Bioengineering, 231-251. United Kingdom & United States: Woodhead Publishing.
    Source Title
    Peptide Applications in Biomedicine, Biotechnology and Bioengineering
    DOI
    10.1016/B978-0-08-100736-5.00009-0
    ISBN
    9780081007426
    School
    Curtin Malaysia
    URI
    http://hdl.handle.net/20.500.11937/72524
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Elsevier Ltd. All rights reserved. In the pharmaceutical industry, organic-based small molecules have been the most widely used therapeutics, but peptides are increasingly becoming an important class of therapeutic agent for biopharmaceutical applications. This trend is enhanced by research advances that have provided cutting-edge techniques and strategies to overcome challenges often encountered with the use of peptides. By their nature, peptide pharmaceutics are plagued with high cost of production, poor solubility, and difficulty in administration. However, the use of techniques such as peptide engineering, peptide conjugation, and formulation strategies to improve parenteral delivery are paving the way for an increased use of peptides as biologics. With these drivers, peptides are anticipated to occupy an increased share of use in the treatment of health conditions, as well as in performance on the therapeutics market. This chapter gives an overview of the drivers, restrains, and advances in the application of peptides as biopharmaceutical agents.

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