Pharmacotherapy for the prevention of malaria in pregnant women: currently available drugs and challenges
MetadataShow full item record
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Malaria in pregnancy continues to be a significant public health burden globally, with over 100 million women at risk each year. Sulfadoxine-pyrimethamine (SP) is the only antimalarial recommended for intermittent preventive therapy in pregnancy (IPTp) but increasing parasite resistance threatens its viability. There are few other available antimalarial therapies that currently have sufficient evidence of tolerability, safety, and efficacy to replace SP. Areas covered: Novel antimalarial combinations are under investigation for potential use as chemoprophylaxis and in IPTp regimens. The present review summarizes currently available therapies, emerging candidate combination therapies, and the potential challenges to integrating these into mainstream policy. Expert opinion: Alternative drugs or combination therapies to SP for IPTp are desperately required. Dihydroartemisinin-piperaquine and azithromycin-based combinations are showing great promise as potential candidates for IPTp but pharmacokinetic data suggest that dose modification may be required to ensure adequate prophylactic efficacy. If a suitable candidate regimen is not identified in the near future, the success of chemopreventive strategies such as IPTp may be in jeopardy.
Showing items related by title, author, creator and subject.
Lee, Crystal; Woodward, M.; Colagiuri, S. (2016)Aim: To estimate and compare the results from all randomised trials of triple combinations of anti-diabetes therapies that reported the reduction of glycated haemoglobin (HbA1c) and associated effects on body weight and ...
Evaluation of the effects of botulinum toxin A injections when used to improve ease of care and comfort in children with cerebral palsy whom are non-ambulant: A double blind randomized controlled trialThorley, M.; Donaghey, S.; Edwards, P.; Copeland, L.; Kentish, M.; McLennan, K.; Lindsley, J.; Gascoigne-Pees, L.; Sakzewski, L.; Boyd, Roslyn (2012)Background: Children with cerebral palsy (CP) whom are non-ambulant are at risk of reduced quality of life and poor health status. Severe spasticity leads to discomfort and pain. Carer burden for families is significant. ...
Yusuf, S.; Lonn, E.; Pais, P.; Bosch, J.; López-Jaramillo, P.; Zhu, J.; Xavier, D.; Avezum, A.; Leiter, L.; Piegas, L.; Parkhomenko, A.; Keltai, M.; Keltai, K.; Sliwa, K.; Chazova, I.; Peters, R.; Held, C.; Yusoff, K.; Lewis, B.; Jansky, P.; Khunti, K.; Toff, W.; Reid, Christopher; Varigos, J.; Accini, J.; McKelvie, R.; Pogue, J.; Jung, H.; Liu, L.; Diaz, R.; Dans, A.; Dagenais, G.; HOPE-3 Investigators (2016)BACKGROUND: Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially. METHODS: ...