Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study

    Access Status
    Fulltext not available
    Authors
    Sarna, Mohinder
    Ware, R.
    Lambert, S.
    Sloots, T.
    Nissen, M.
    Grimwood, K.
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Sarna, M. and Ware, R. and Lambert, S. and Sloots, T. and Nissen, M. and Grimwood, K. 2018. Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study. Journal of Infectious Diseases. 217 (3): pp. 418-427.
    Source Title
    Journal of Infectious Diseases
    DOI
    10.1093/infdis/jix599
    ISSN
    0022-1899
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/72589
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 The Author(s). Background. Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors associated with increased odds of symptomatic fVDEs. Methods. The Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday. Parents recorded daily symptoms and collected nose swabs weekly, which were batch-tested using polymerase chain reaction assays for 17 respiratory viruses. Results. One hundred fifty-eight infants participated in ORChID. The median age for fVDEs was 2.9 months for human rhinovirus (HRV) but was =13.9 months for other respiratory viruses. Overall, 52% of HRV fVDEs were symptomatic, compared with 57%.83% of other fVDEs. Respiratory syncytial virus and human metapneumovirus fVDEs were more severe than HRV fVDEs. Older age and the winter season were associated with symptomatic episodes. Conclusions. Infants do not always experience respiratory symptoms with their fVDE. Predominance of early HRV detections highlights the need for timing any intervention early in life. fVDEs from other respiratory viruses most commonly occur when maternal vaccines may no longer provide protection.

    Related items

    Showing items related by title, author, creator and subject.

    • Breastfeeding and health outcomes in infants who receive continuing care from hospitals or community health centres in Chengdu Sichuan Province, People’s Republic of China
      Yu, Chuan (2013)
      Introduction. The child health is one of the most important indicators of population health and the development of society. The health of children in China has improved in the past decades. The child health care system ...
    • Viruses causing lower respiratory symptoms in young children: Findings from the ORChID birth cohort
      Sarna, Mohinder; Lambert, S.; Sloots, T.; Whiley, D.; Alsaleh, A.; Mhango, L.; Bialasiewicz, S.; Wang, D.; Nissen, M.; Grimwood, K.; Ware, R. (2018)
      © 2018 Article author(s). Introduction Viral acute respiratory infections (ARIs) cause substantial child morbidity. Sensitive molecular-based assays aid virus detection, but the clinical significance of positive tests ...
    • Frequent nocturnal awakening in early life is associated with nonatopic asthma in children
      Kozyrskyj, A.; Kendall, Garth; Zubrick, Stephen; Newnham, J.; Sly, Peter (2009)
      Frequent nocturnal awakening in early life is associated with nonatopic asthma in children Holdings more options Author(s): Kozyrskyj AL (Kozyrskyj, A. L.)1,2, Kendall GE (Kendall, G. E.)3,4,6, Zubrick SR ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.