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dc.contributor.authorArora, L.
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorArfuso, Frank
dc.contributor.authorChng, W.
dc.contributor.authorSethi, G.
dc.date.accessioned2018-12-13T09:14:07Z
dc.date.available2018-12-13T09:14:07Z
dc.date.created2018-12-12T02:47:03Z
dc.date.issued2018
dc.identifier.citationArora, L. and Kumar, A.P. and Arfuso, F. and Chng, W. and Sethi, G. 2018. The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies. Cancers. 10 (9): 327.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/72647
dc.identifier.doi10.3390/cancers10090327
dc.description.abstract

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo-or heterodimers that can translocate to the cell nucleus where they act as transcription activators. Constitutive activation of STAT3 has been found to be associated with initiation and progression of various cancers. It can exert proliferative as well as anti-apoptotic effects. This review focuses on the role of STAT3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. leukemia, lymphoma and myeloma, and briefly highlights the potential therapeutic approaches developed against STAT3 activation pathway.

dc.publisherMDPI AG
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies
dc.typeJournal Article
dcterms.source.volume10
dcterms.source.number9
dcterms.source.issn2072-6694
dcterms.source.titleCancers
curtin.departmentCurtin Medical School
curtin.accessStatusOpen access


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